Histologically, basal cell adenomas are classified as monomorphic tumors composed chiefly of basaloid cells organized with a prominent basal cell layer and distinct basement membrane–like material.
They lack the myxochondroid stromal component of pleomorphic adenomas [2]..
Basal cell adenomas are unique benign salivary gland tumors affecting women over 50 years of age comprising 1–3% of all salivary gland tumors. [1,2] Cytologically, they mimic several benign and malignant salivary and non-salivary gland tumors, warranting thorough histopathological examination.Mar 9, 2015.
Histologically, basal cell adenomas are classified as monomorphic tumors composed chiefly of basaloid cells organized with a prominent basal cell layer and distinct basement membrane–like material.
They lack the myxochondroid stromal component of pleomorphic adenomas [2]..
Synonyms.
Tubular adenoma, trabecular adenoma, dermal analogue tumor, basaloid adenoma, and monomorphic adenoma.May 31, 2017.
Basal cell adenoma (BCA) of the salivary gland is a rare neoplasm consists of a monomorphic population of basaloid epithelial cells, and it accounts for approximately 1–2 % of all salivary gland tumors.
Its most frequent location is the parotid gland.
It usually appears as a firm and mobile slow-growing mass..
In basal cell adenoma, the cells are intermingled with adjacent stroma, whereas in adenoid cystic carcinoma, the cells and stroma are sharply demarcated [8, 9].
Sometimes few vessels or spindle cells can be seen in stroma of basal cell adenoma, but the stromal globules of adenoid cystic carcinoma are acellular [9]..
Solid type is most common histopathologic type followed by tubular, membranous and trabecular..
Moreover, pleomorphic adenoma with predominant basal cells and solid / tubular variant of adenoid cystic carcinoma can also cytologically mimic a basal cell adenoma.
Therefore, it is recommended to report FNA with basal cell features as SUMP with basaloid features in the Milan system.
Basal cell adenoma can have somewhat unique cytologic and ancillary findings that can suggest the diagnosis at FNA, such as:
Some patients can have a membranous basal cell adenoma of the salivary gland.
It is caused by germline mutations in the CYLD gene (16q12-q13).
Which of the following markers is most useful to differentiate tubular / trabecular predominant basal cell adenoma from pleomorphic adenoma.
A.
Beta catenin.
J Oral Maxillofac Pathol. 2015 Jan-Apr; 19 (1):
