Thyroid cytology giant cells

  • What are giant cells in papillary thyroid cancer?

    Multinucleated foreign body–type giant cells (MGCs), seen in benign and malignant lesions of the thyroid gland, are most commonly identified in papillary carcinoma,7,10 Hashimoto's thyroiditis and granulomatous thyroiditis..

  • What are Multinucleated giant cells in thyroid FNAC?

    Multinucleate giant cells (MGCs) occur in a variety of inflammatory, hyperplastic, and neoplastic thyroid disorders.
    They also have been recognized as a feature of papillary thyroid carcinoma (PTC), particularly in fine-needle aspiration biopsies (FNAB)..

  • The tall cell variant (TCV) of papillary thyroid carcinoma (PTC) is characterized by tall columnar cells with a height of at least three times their width.
    TCV usually presents at an older age, has a larger size and exhibits more extrathyroidal extension and metastases than classical PTC.
  • Ultrasound-guided fine needle aspiration (FNA) of the thyroid refers to a minimally invasive procedure where in which tissue samples are collected from a thyroid nodule or other suspicious thyroid lesion.
    It is usually done on an outpatient basis and generally complications are very minimal.
Multinucleated giant cells (MGCs) are often associated with papillary thyroid carcinoma (PTC). While their presence has been well-documented in cytologic preparations, there are relatively few studies of MGCs in histologic sections of PTC.
Multinucleated giant cells (MGCs) are often detected in cases of papillary thyroid carcinoma (PTC). Their origin and significance, however, has not been established. One possibility is that they form in response to injury induced by fine needle aspiration biopsy (FNAB).
Multinucleated giant cells (MNGCs) are reported in many thyroid lesions. This study examines whether their quantity and quality can help in the differential 

Can multinucleated giant cell features help cytopathology practice?

BACKGROUND Multinucleated giant cell (MGC) present in a variety of non-neoplastic and neoplastic lesions of the thyroid on cytology samples

We aimed to investigate whether certain MGC features that can help us in routine cytopathology practice

Can multinucleated giant cells help in the differential diagnosis of thyroid lesions?

Multinucleated giant cells (MNGCs) are reported in many thyroid lesions

This study examines whether their quantity and quality can help in the differential diagnosis

All fine-needle aspirations (FNAs) of the thyroid with a "significant" number of MNGCs were reviewed from 1995 -1998

What does thyroid cytology look like?

Thyroid Cytology Must see at least 6 groups of well-visualized follicular epithelial cells, each consisting of at least 10 cells

nice big, flat (“monolayered”) sheets, with evenly nuclei with uniformly granular chromatin

Histologically represent nodular goiter, adenomatoid nodules, and colloid nodules


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