Tophi are large, visible bumps made of urate crystals. “They can form in joints, bone, or cartilage,” says Kaitlin A.
Quinn, MD, a rheumatologist at Medstar Georgetown University Hospital.
You might find them on your elbow, hands, feet, or the outer edge of your ear..
Tophi are large, visible bumps made of urate crystals. “They can form in joints, bone, or cartilage,” says Kaitlin A.
Quinn, MD, a rheumatologist at Medstar Georgetown University Hospital.
You might find them on your elbow, hands, feet, or the outer edge of your ear..
A subcutaneous tophus is a well-organized collection of monosodium urate crystals and is pathognomonic for gout, as is the destructive arthritis of advanced gout.
Tophi can lead to pain and dysfunction in their own right..
Demonstration of urate crystals in synovial fluid or biopsy helps in confirming the diagnosis of gout.
However, fine-needle aspiration cytology (FNAC) of periarticular soft-tissue nodules is a valuable tool in the diagnosis of gout.Aug 5, 2022.
Histologically, gout y tophi appear as amorphous amphophilic material similar to amyloid deposits (figure 2, A)..
Histologically, gout y tophi appear as amorphous amphophilic material similar to amyloid deposits (figure 2, A)..
Aspirates from gouty tophi are largely comprised of the crystalline component (May–Grunwald Giemsa stain; original magnification, ×250)
One potential pitfall in aspiration cytology is distinguishing the contents of a gouty tophus from a deposit of pseudogout
The tophus is the cardinal feature of advanced gout
This review summarises recent research into the biology, impact and treatment of tophaceous gout
Microscopically, tophi are chronic foreign body granuloma-like structures containing collections of monosodium urate (MSU) crystals surrounded by inflammatory cells and connective tissue
Histologic features are consistent with gout (see comment) Comment: Biopsy shows fibroadipose tissue exhibiting nodular aggregates and granulomatous appearance of acellular, amorphous, pale eosinophilic material surrounded by palisading arrangement of histiocytes and multinucleated giant cells
