Statistical cell analysis

  • How is statistics used in biology?

    Using the tools of statistics, biostatisticians help answer pressing research questions in medicine, biology and public health, such as whether a new drug works, what causes cancer and other diseases, and how long a person with a certain illness is likely to survive..

  • In biochemistry, statistical methods are used to determine the relationships between variables, make predictions, and test hypotheses.
    This helps to identify patterns and trends in the data and make reliable conclusions about biological systems and processes.
We provide guidelines for using statistical methods to analyze the types of experiments reported in cellular and molecular biology journals such as  PERSPECTIVESEVEN STEPSCONCLUSIONSTATISTICS TUTORIAL

Can statistical methods be used to analyze cellular and molecular biology experiments?

Mol Biol Cell. 2019 Jun 1; 30 (12):

  1. 1359–1368

We provide guidelines for using statistical methods to analyze the types of experiments reported in cellular and molecular biology journals such as:Molecular Biology of the Cell.
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How can single-cell analysis help diagnose cancer?

In this Perspective, Teschendorff and Feinberg describe how single-cell analysis methods based on statistical mechanics can provide valuable insights into developmental phenomena, such as:

  1. differentiation potency and lineage trajectories
  2. as well as disruption of these processes in cancer
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What is single-cell RNA sequencing data analysis?

In the context of single-cell RNA sequencing data analysis, this refers to a filtering step whereby all cells passing quality control are used to select genes according to some statistical criterion (for example, high variability across cells).

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What methods are used in a single cell analysis?

The seven single-cell methods analyzed here included a t-test, a Wilcoxon rank-sum test, logistic regression 39, negative binomial and Poisson generalized linear models, a likelihood ratio test 40, and the two-part hurdle model implemented by MAST 7.


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