How do you treat CBDC disease?
Usually, children of CBDC respond very well to oral dapsone along with topical steroids.
In refractory cases, reports of flucloxacillin, erythromycin, tetracycline, nicotinamide, colchicines, methotrexate, ciclosporin, IVIG, azathioprine, mycophenolate, and immunoadsorption have been employed successfully..
How do you treat CBDC?
Usually, children of CBDC respond very well to oral dapsone along with topical steroids.
In refractory cases, reports of flucloxacillin, erythromycin, tetracycline, nicotinamide, colchicines, methotrexate, ciclosporin, IVIG, azathioprine, mycophenolate, and immunoadsorption have been employed successfully..
How is chronic bullous disease of childhood diagnosed?
How is it diagnosed? A skin biopsy is usually needed to confirm the diagnosis.
If the child has chronic bullous disease, his or her blood test will show higher levels of antibodies than usual..
What is a CBDC in dermatology?
CBDC is a rare blistering skin disease characterized by the presence of tense bullae and the linear deposition of IgA at the dermal-epidermal junction of lesional and perilesional skin.
The disease may resemble bullous impetigo, bullous erythema multiforme, dermatitis herpetiformis, or pemphigus..
What is a CBDC skin disease?
CBDC is a rare blistering skin disease characterized by the presence of tense bullae and the linear deposition of IgA at the dermal-epidermal junction of lesional and perilesional skin.
The disease may resemble bullous impetigo, bullous erythema multiforme, dermatitis herpetiformis, or pemphigus..
What is chronic bullous dermatosis of childhood?
Chronic bullous disease of childhood is a rare autoimmune skin condition which results in clusters of blisters developing in rings often on the face or genitals.
In autoimmune disorders, antibodies – which usually seek and destroy foreign invaders to the body, such as viruses – attack the body's own cells instead..
What is the cause of bullae?
Friction.
One of the most common causes of bullae is friction.
This includes the friction that occurs from using a shovel or another tool, or rubbing against the inside of a shoe.
Friction blisters appear most often on your hands and feet..
What is the prognosis for CBDC?
Prognosis is generally favorable, with spontaneous remission usually occurring by puberty; however, cases with severe morbidity and cases persisting into adulthood have been reported.
This article discusses the clinical features, diagnosis, and pathogenesis of CBDC in more detail..
- A biopsy for hematoxylin and eosin staining will show a subepidermal split with eosinophils, and direct immunofluorescence will highlight the autoantibodies against the basement membrane zone.
ELISA testing is also useful in diagnosing bullous pemphigoid. - Linear IgA bullous disease usually improves or clears when treated with dapsone, an immunomodulatory sulphone.
Its success as treatment is well-established and improvement can usually be seen within just 2 to 3 days of drug initiation. - Prognosis is generally favorable, with spontaneous remission usually occurring by puberty; however, cases with severe morbidity and cases persisting into adulthood have been reported.
This article discusses the clinical features, diagnosis, and pathogenesis of CBDC in more detail.