Experimental design and analysis in animal sciences pdf

  • How are animals used in experimental research?

    Animals are needed in research to develop drugs and medical procedures to treat diseases.
    Scientists may discover such drugs and procedures using research methods that do not involve animals.
    If the new therapy seems promising, it is then tested in animals to see whether it seems to be safe and effective..

  • What are the fundamental steps in experimental design for animal studies?

    During the preparation of the study design, investigators should hold his attention in planning important steps before starting the study.
    These include the number of animals to be used, pilot studies, randomization, blinding, control groups, type of variables collected, and the statistical methods1,4,9..

  • What is experimental animal science?

    An animal model is defined as a laboratory animal used in biomedical research that simulates processes seen in human disease for the purpose of better understanding the disease..

  • Animals are needed in research to develop drugs and medical procedures to treat diseases.
    Scientists may discover such drugs and procedures using research methods that do not involve animals.
    If the new therapy seems promising, it is then tested in animals to see whether it seems to be safe and effective.
  • During the preparation of the study design, investigators should hold his attention in planning important steps before starting the study.
    These include the number of animals to be used, pilot studies, randomization, blinding, control groups, type of variables collected, and the statistical methods1,4,9.
  • Here is a selection of common animal procedures: Forced chemical exposure in toxicity testing, which can include oral force-feeding, forced inhalation, skin or injection into the abdomen, muscle, etc.
    Exposure to drugs, chemicals or infectious disease at levels that cause illness, pain and distress, or death.

How do you design an animal experiment?

A null and an alternate hypothesis that address the problem statement are then formulated, and only then is the specific design of the experiment developed

Likely the most critical step in designing animal experiments is the identification of the most appropriate animal model to address the experimental question being asked

How to increase the scientific validity of animal experiments?

To increase the scientific validity of the results and maximize the knowledge gained from animal experiments, each experiment should be appropriately designed, and the observations need to be correctly analyzed and transparently reported

There are many experimental designs and statistical methods

Why should experiments involving animals be properly analyzed?

For scientific, ethical, and economic reasons, experiments involving animals should be appropriately designed, correctly analyzed, and transparently reported

This increases the scientific validity of the results and maximizes the knowledge gained from each experiment


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