How to design a bioreactor?
The design parameters for an ideal bioreactor include reduction of mass transfer resistances and elimination of substrate limitations so that the device can function at maximum efficiency and minimize the dead volume within the device, thereby reducing the effects of plasma dilution in the patient..
What are the design criteria for a bioreactor?
Some important factors in bioreactor design are (i) sterility, (ii) broth rheology, (iii) mass transfer, (iv) mixing, (v) heat transfer, (vi) suspension homogenization, and (vii) shear sensitivity of microorganisms..
What are the design criteria for bioreactors?
The main criteria for the selection of bioreactors include culture conditions required for the selected microorganisms, simplicity in operation, scalability, material demand, and the cost of the equipment..
What are the design factors for bioreactors?
Some important factors in bioreactor design are (i) sterility, (ii) broth rheology, (iii) mass transfer, (iv) mixing, (v) heat transfer, (vi) suspension homogenization, and (vii) shear sensitivity of microorganisms..
What are the factors to consider when designing a bioreactor?
Typically, a bioreactor consists of a container, an agitator, and a means of controlling temperature, pH, and other environmental factors.
The container can be made of glass or stainless steel and has ports for adding nutrients, removing waste, and monitoring the progress of the culture..
What is bioreactor design parts and their function?
This bioreactor is consists of different types of parts such as “an agitator system”, “A foam control system”, “Baffles system”, “PH & temperature control system”, “Farmentar vessel”, “Aeration system” and “An Impeller system”.
Each of these parts has its own necessary usage to perform this bioreactor..
What is the design of bioreactor?
The bioreactor used for the growth of Dermagraft consists of a bag with eight cavities welded into it, each of which contains a sheet of the scaffold.
Such bags are attached in groups of 12 to manifolds, with a solid support, for cell, medium or cryopreservative addition, to form a system..
What should be the criteria for designing a bioreactor?
Sterile conditions must be maintained for pure culture system.
Effective agitation is required for uniform distribution of substrate and microbes in the working volume of the bioreactor.
Heat transfer is needed to operate the bioreactor at constant temperature, as the desired optimal microbial growth temperature..
- Controlling the key parameters of a bioreactor, such as temperature, pH, pure O2 (pO2), agitation, and pressure are essential to maintain cells in a physical and chemical environment, optimizing their performance.
- This bioreactor is consists of different types of parts such as “an agitator system”, “A foam control system”, “Baffles system”, “PH & temperature control system”, “Farmentar vessel”, “Aeration system” and “An Impeller system”.
Each of these parts has its own necessary usage to perform this bioreactor.
