1 - Each heavy and light chain is made up of a number of domains (= Ig folding or Ig domains) - Light chains consist of 2 domains (C and V) - Heavy chains have 4-5 domains (depending on the class of antibody)
What is a B cell antibody?
An antibody (formally called immunoglobulin) is a large Y-shaped glycoprotein produced by B-cells and used by the immune system to identify and neutralize pathogens. Antibodies are produced by B cells, and are either secreted into circulation or remain expressed on the surface of the B cell.
How do antibodies bind to a specific antigen?
Antibody: Each antibody binds to a specific antigen, an interaction similar to a lock and key. Antibodies are glycoproteins belonging to the immunoglobulin superfamily, typically made of basic structural units each with two large heavy chains and two small light chains.
How many AA units are in an antibody?
Antibodies are comprised of repeating 110 aa units referred to as domains or Ig folds. - The C-terminal domains are constant from antibody to antibody (within a class). - The constant region domains are responsible for all functions of antibody other than antigen binding (opsonization, ADCC, complement activation) Biological Function!
How are antibodies produced?
Antibodies are produced by B cells, and are either secreted into circulation or remain expressed on the surface of the B cell. The antibody recognizes a unique part of an antigen (foreign object).
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