ac2o dmap mechanism

What is the mechanism of DMAP acetylation?

(17) reported a two-step mechanism for DMAP-catalyzed acetylation (Scheme 1); in step 1, DMAP reacts with acetic anhydride to form N-acetylated DMAP acetate (I), and in step 2, the alcohol substrate attacks I to form a transient intermediate that leads to the ester product after proton transfer and simultaneous release

What is the mechanism of DMAP tea?

DMAP attacks a carbonyl site on di-tert-butyl dicarbonate (Boc2O) resulting in tert-butyl carbonate leaving as a leaving group.
The amine attacks the carbonyl site on the boc-pyridinium species resulting in the release of DMAP (catalytic).
The base (usually TEA or DIEA) picks up the proton from the protonated amine.

What is the mechanism of the DMAP reaction?

This mechanism involves the formation of the acylpyridinium ion pair from the reaction of the DMAP catalyst with the acyl donor; later, the alcohol reacting with the acylated catalyst in the rate-determining second step and forming the ester product with the protonated catalyst.

A better explanation for DMAP being such an effective catalyst is that it reacts with acid chlorides, such as 12, to form high concentrations of N‑acylpyridinium salts (eq 7).
These salts are better able to transfer an acyl group to a nucleophile than is the acid chloride itself.