Aldh1l2 knockout mouse metabolomics links the loss of the
Here we address the role of ALDH1L2 in cellular metabolism and highlight the mechanism by which the enzyme regulates lipid oxidation.
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ALDH1L2 Knockout in U251 Glioblastoma Cells Reduces Tumor
30 avr. 2022 The knockout of ALDH1L2 gene in U251 cells rendered the growth of the ... ROS level plays a key role in the control of stem cell fate as a ...
Deleterious mutations in ALDH1L2 suggest a novel cause for neuro
18 sept. 2019 ALDH1L2 impairs the mitochondrial function and is the likely cause of a new neuro-ichthyotic syndrome. Characterization of patient's fibroblasts.
The one-carbon metabolism pathway highlights therapeutic targets
MTHFD2 and ALDH1L2 which play critical roles in the cancer survival and proliferation presumably through purine production. In the methionine cycle
ALDH1L2 Knockout in U251 Glioblastoma Cells Reduces Tumor
30 avr. 2022 The knockout of ALDH1L2 gene in U251 cells rendered the growth ... ROS level plays a key role in the control of stem cell fate as a high ROS ...
Enzymatic properties of ALDH1L2 a mitochondrial 10
14 janv. 2011 ALDH1L2 has enzymatic properties similar to its cytosolic counterpart ... that FDH broadly functions to regulate folate-mediated one-carbon.
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The importance of mitochondrial folate enzymes in human colorectal
dehydrogenase 1 family member L2 (ALDH1L2) were upreg- ulated in human colorectal tumor Folate plays a pivotal role in the one-carbon metabolism.
The mitochondrial one‑carbon metabolic pathway is associated with
17 mars 2017 one-carbon metabolism serves a significant role in malig- nant cancer phenotypes. ... dehydrogenase 1 family member L2 (ALDH1L2) and serine.
Mitochondrial One-Carbon Pathway Supports Cytosolic Folate
29 nov. 2018 This role of QDPR can explain the folate deficiency in ... The mitochondrial isoform ALDH1L2 is expected to facilitate.
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Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the
30 oct. 2015 duce mitochondrial NADPH via the enzyme ALDH1L2 and ... tant role in regulating the cytosolic flux of 1C units through the.
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