Destruct and arrest
10 déc. 2008 Indeed the use of small interfering RNAs. (siRNAs) against APC/C or the SAC protein MAD2 blocked CDC20 degradation
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The Spindle Assembly Checkpoint Is Not Essential for Viability of
18 févr. 2016 Reduction in APC/C activity renders the SAC unessential in human cells d. UBE2C-UBE2S deletion provides synthetic viability to MAD2 deletion.
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The ABBA Motif Binds APC/C Activators and Is Shared by APC/C
9 févr. 2015 checkpoint (SAC). How the APC/C recognizes its different substrates is a key problem in the control of cell division.
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The PP2AB56 phosphatase promotes the association of Cdc20 with
promotes silencing of the spindle assembly checkpoint (SAC) APC/CCdc20 inhibitor formed at unattached kinetochores through SAC signaling.
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The ABBA Motif Binds APC/C Activators and Is Shared by APC/C
9 févr. 2015 This motif mediates binding of these proteins to the APC/C activator Cdc20 and is required for SAC function and timely cyclin A degradation.
A dual mechanism of APC/C inhibition by MAP kinases
3 avr. 2022 anaphase-promoting complex/cyclosome (APC/C) activity upon activation of the. 42 spindle assembly checkpoint (SAC).
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Molecular mechanisms of APC/C release from spindle assembly
30 mars 2021 Its regulation by the spindle assembly checkpoint (SAC) is coordinated with the attachment of sister chromatids to the mitotic spindle. APC/C ...
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Article - The APC/C Subunit Mnd2/Apc15 Promotes Cdc20
SAC-dependent Cdc20 autoubiquitination required the Mnd2/Apc15 subunit of the APC/C. General inhi- bition of Cdc20 ubiquitination in vivo resulted in high.
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Non-canonical function of spindle assembly checkpoint proteins
18 mars 2014 The spindle assembly checkpoint (SAC) prevents aneuploidy by coupling anaphase onset through anaphase-promoting complex (APC) activation
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TORC1 inactivation promotes APC/C-dependent mitotic slippage in
18 févr. 2022 The spindle assembly checkpoint (SAC) ensures faithful chromosome segregation during cell division. (Bharadwaj and Yu 2004; Musacchio and ...
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