reactivity of carboxylic acid derivatives
REACTIONS OF CARBOXYLIC ACIDS & DERIVATIVES
hexanedioic acid adipic acid HO2CCH2CH2CH2CH2CO2H Reactions of carboxylic acids and their derivatives (acyl halides, anhydrides, esters, amides) |
Chapter 21: Carboxylic Acid Derivatives
The reactivity of acid derivatives can be correlated to the leaving group ability of the base that is expelled The better the leaving group, the more reactive will be the acid derivative Not surprising that acid chloride are the most reactive derivatives |
85 Chapter 20: Carboxylic Acid Derivatives: Nucleophilic Acyl
ester amide acid chloride acid anhydride |
100 Chapter 21 Carboxylic Acid Derivatives and Nucleophilic Acyl
acid ester amide acid chloride acid anhydride thioester acyl phosphate Increasing reactivity Relative reactivity of carboxylic acid derivatives: The mechanism |
Reactions of Carboxylic Acid Derivatives I
Different carboxylic acid derivatives have very different reactivities, acyl chlorides and bromides being the most reactive and amides the least reactive, as noted in |
Carboxylic Acid Derivatives Addition/Elimination
Definition: A carboxylic acid derivative undergoes hydrolysis (bond breaking with water) The same reactivity order is found for acid derivatives in all reactions |
Nucleophilic Reactions of Carboxylic Acid Derivatives
carboxylic acids, are named by alphabetizing the names for both acids and replacing the word acid with the word anhydride Nomenclature—Anhydrides Page 9 |
Functional Derivatives of Carboxylic Acids
14 2 What Are the Characteristic Reactions of Carboxylic Acid Derivatives? The most common reaction theme of acid halides, anhydrides, esters, and amides is |