succinic anhydride reaction with amine


What is the reaction kinetics of succinic anhydride with amine-containing drugs?

The reaction kinetics of succinic anhydride with amine-containing drugs benzocaine, procaine and sulfanilamide was studied. It is shown that the reaction in the initial period is autocatalytic; subsequently the amidation process is dominant, which corresponds to second order reaction type.

How do acid anhydrides react with amines to form amides?

Acid Anhydrides react with amines to form amides General Reaction Example 1: Mechanism 1) Nucleophilic Attack by the Amine 2) Deprotonation by the amine 3) Leaving group removal Contributors Prof. Steven Farmer (Sonoma State University) Back to top Acid Anhydrides react with alcohols to form esters

How do you block dendrimer amines with succinic anhydride?

Reactions with succinic anhydride or acetic anhydride to block dendrimer amines can be done in aqueous or methanolic solution. If organic solvent is used for the reaction, then it is typical to include triethylamine as a proton acceptor, which helps drive the reaction.

What is the molecular formula for succinic anhydride?

The molecular formula for succinic anhydride is C 4 H 4 O 3 . This is the chemical structure of sulfanilamide. Ben Mills/PD The molecular formula for sulfanilamide is C 6 H 8 N 2 O 2 S. This is the chemical structure of sulfanilic acid. NEUROtiker/PD The molecular formula for sulfanilic acid is C 6 H 7 NO 3 S.

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