surgical antibiotic prophylaxis guidelines 2019 pdf


  • WHO guidelines for antibiotic prophylaxis in surgery?

    Right timing of administration
    Most guidelines, including Therapeutic Guidelines: Antibiotic, recommend that preoperative intravenous antibiotics be given within 60 minutes of incision. More recently, the World Health Organization recommended administration within 120 minutes of incision.
  • What is the antibiotic of choice for surgical prophylaxis?

    The three antibiotics used in adult surgical prophylaxis, where weight-based dosing is recommended, are cefazolin, vancomycin, and gentamicin.
  • How long is postoperative antibiotic prophylaxis?

    National guidelines recommend that surgical antimicrobial prophylaxis be initiated within 1 hour prior to incision and discontinued within 24 hours postoperatively for most procedures and within 48 hours for cardiac surgery.
  • Ampicillin 2 grams (pediatric dose 50 mg/kg) IV or IM within 60 minutes prior to procedure. If penicillin hypersensitivity: Clindamycin 600 mg (pediatric dose 20 mg/kg) orally within 60 minutes before procedure or 900 mg IV (pediatric dose 10 mg/kg IV) within 60 minutes prior to procedure.
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