pas positive diastase resistant globules
What causes PAS-positive diastase-resistant globules?
They were always present in the centrilobular areas and most likely were the result of sinusoidal congestion and anoxia. The immunocytochemical method is useful in separating the two types of PAS-positive, diastase-resistant globules. Type 1 inclusions are associated with alpha 1 antitrypsin deficiency.
Are cytoplasmic PAS diastase positive globules compatible with Alpha-1 antitrypsin defic?
Hepatocytes with cytoplasmic PAS diastase positive globules compatible with alpha-1 antitrypsin deficiency Comment: Immunohistochemistry for AAT is positive in the cytoplasmic globules and supports the diagnosis. Correlation with laboratory findings is recommended.
Are PAS-positive diastase-resistant globules a symptom of alcoholic cirrhosis?
For instance, PAS-positive diastase-resistant globules are known to occur in end-stage liver disease, including alcoholic cirrhosis, in the absence of AAT deficiency. 3, 4 Studies by Popper et al 5 and Biava 6 also described PAS-positive diastase-resistant structures in normal as well as abnormal liver tissue.
What are PAS-positive diastase-resistant hepatocyte inclusions?
In seven of these patients, PAS-positive, diastase-resistant inclusions were seen in the hepatocytes; in two patients, these inclusions contained a material antigenically similar to alpha-1-antitrypsin. These inclusions might represent deposits of glycoproteins poorly excreted by the diseased hepatocytes.
Abstract
The presence of periodic acid-Schiff–positive (PAS) diastase-resistant globules has been well documented in the hepatocytes of patients affected by α-1-antitrypsin (AAT) deficiency. These globules are usually characteristically distributed in zone 1 (periportal) of the hepatic lobule and are positive by immunohistochemistry (IHC) with antibodies di
Material and Methods
We retrospectively reviewed our pathology database for liver biopsies obtained between January 1994 and January 2018 showing features characteristic of venous outflow impairment (VOI). These features included zone 3 congestion, sinusoidal dilatation Image 1A, hepatocellular plate atrophy, and erythrocyte (RBC) extravasation, with or without perisin
Results
A total of 64 liver biopsies were reviewed. Among these biopsies, 31 subjects were male and 33 were female. The mean age at biopsy was 49 years (range, 18-84 years). The causes of hepatic congestion included: 11 cardiac congestion, 21 Budd-Chiari syndrome, and seven amyloidosis. The clinical findings in the remaining cases were consistent with VOI,
Discussion
The current study analyzed, in a well-characterized sample of eight patients, the prevalence and clinopathologic aspects of a relatively rare histologic finding, that is hepatocellular cytoplasmic globules in the setting of VOI and in the absence of ATT deficiency. Besides the typical AAT-deficiency globules, PAS-positive diastase-resistant hepatoc
Conclusions
Based on our current study, PAS-positive diastase-resistant cytoplasmic globules, although relatively rare, can occur in the hepatocytes of adult individuals affected by VOI, regardless the cause of the impairment. These globules are positive for AAT by immunostain but can be distinguished from AAT globules by their appearance, lack of zone 1 local
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Alpha1 Antitrypsin Liver Disease Differential Diagnosis of PAS
In 500 consecutive autopsies there were 27 cases in which the livers contained PAS-positive diastase-resistant globules within hepatocytes. |
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Letter to the editor leukocyte inclusions in glycogen storage disease
The intracytoplasmic inclusions stain with PAS and resist diastase digestion but positive diastase-resistant globules (Fig. 1C). |
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Letter to the editor leukocyte inclusions in glycogen storage disease
The intracytoplasmic inclusions stain with PAS and resist diastase digestion but positive diastase-resistant globules (Fig. 1C). |
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Alpha-1-Antitrypsin Deficiency: A New Paradigm for Hepatocellular
after treatment with diastase the so-called PAS-positive/ diastase-resistant globules. Early studies showed that these globules represent the mutant |
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Alphaâ•1â•antitrypsin deficiency in Southern African hepatocellular
Jun 15 1982 No periportal PAS-positive diastase-resistant globules containing AAT. (specific for AATD) were found in liver tissue from either group. |
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ANATOMIC PATHOLOGY Original Article H e p a t o c y t i c G
Nov 20 1996 hepatic disease other than A^T deficiency. PAS-positive diastase- resistant globules were detected in 17 (10%) of the hepatic explant. |
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Undifferentiated (embryonal) sarcoma of the liver with alphaâ•1â
Jun 15 1980 liver with tumor cell deposits of PAS-positive |
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Ultrastructural Liver Pathology in Patients with Minimal Liver
shown the presence of periodic acid-Schiff (PAS) positive diastase-resistant globules in periportally located hepa- tocytes (1-3 7 |
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Hepatic Hyaline Globules in an Eclectus Parrot (Eclectus Roratus)
Hepatic hyaline globules similar to those reported in some human livers |
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Signetâ•ring sinus histiocytosis
Jul 15 1997 histiocytes with rounded |
| Liver disease in infancy: histological features and |
| Papers - Journal of Clinical Pathology |
| Leading article Alpha-1 antitrypsin de?ciency |
| Research Article Role of Diastase Resistant Periodic Acid |
| Laboratory Use Only PAS-Diastase (PAD) Stain |
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Positive, Diastase-resistant Globules in Liver Cells
Alpha1 Antitrypsin Liver Disease Differential Diagnosis of PAS- Positive, Diastase-resistant Globules in Liver Cells ALI QIZILBASH, M B , B S , F R C P (C) AND |
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Hepatopathology for Gastroenterologists and Hepatologists
Kupffer cells filled with PAS-positive material resistant to diastase digestion ( Some of them globules which indicate α-1 antitrypsin deficiency are PAS positive |
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Liver disease in infancy - Journal of Clinical Pathology
3 mar 1975 · Distinctive, diastase-resistant, PAS-positive, pure magenta-coloured, sharply defined globules, 2-20 microns in diameter were found in |
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Alpha-l-antitrypsin globules in the liver and PiM phenotype
characteristic periodic acid-Schiff (PAS) positive, diastase-resistant globules in the periportal hepato- cytes These globules contain accumulations of antitrypsin |
