qcm-d review
How quartz sensors are applied in QCM-D devices?
Quartz sensors are applied in the QCM-D devices as a mechanical oscillation of characteristic frequency can be produced on the crystal by applying an alternated electric field.
Can QCM-D detect VOCs?
QCM-D is a technology suitable for gas sensing by monitoring changes in mass (due to gas sorption), and so far, many groups have detected VOCs via QCM-D monitoring of polymer films. As shown in Figure 10 (A), when VOC gas molecules are adsorbed onto the polymer-coated-QCM-D sensor, the mass of the polymer increases.
How do you measure QCM?
This signal is recorded, also yielding two parameters per overtone, the resonance frequency fn and the dissipation Dn (Figure 1 D). Bandwidth and dissipation are equivalent, with Dn = 2Γ n / fn (Figure 1 C,D). We will use both terms interchangeably. The third way to perform QCM measurements is with oscillator circuits.
Introduction
Quartz crystal microbalance with dissipation monitoring (QCM-D) is an easy, highly versatile as well as highly sensitive method to study processes occurring at the surfaces or within thin films. QCM was introduced in 1960s to monitor layer formation in vacuum and air thanks to the high mass sensitivity of the 5 MHz quartz system (0.057 Hz cm2 ng−1)
QCM-D as A Tool to Monitor Cell Adhesion
QCM-D sensors was applied in the study of cell-surface interactions as the piezoelectric mass sensing combined with the monitoring of dissipation changes was related to different colonization stages of cells on surfaces (as attachment, adhesion, and spreading; Saitakis and Gizeli, 2012; Tymchenko et al., 2012). When a cell is interacting with the s
QCM-D as A Tool to Monitor Cytotoxicity and Cell Viability
Cells are highly sensitive to perturbations in the surrounding environment and changes interfering with the cell activities can lead to cell death. The monitoring of cell behavior when cells are in contact with bioengineered surfaces, biomaterials, or drugs is fundamental to identify cytotoxic or non-cytotoxic effects. Traditional methodologies to
QCM-D as A Tool to Monitor Important Phenomena in Cells
The opportunity to detect in real time the rearrangement of cell cytoskeleton through QCM-D technology is of pivotal importance in the monitoring of cell biological phenomena such as cell migration and cell differentiation. Data collected by the microgravimetric analyses using the QCM-D system could give information on biological mechanisms which a
Conclusion and Future Perspectives
The collected literature highlighted the role of QCM-D technology as a new and non-conventional facility to monitor cells in real time using a label-free methodology. Several phenomena can be detected from initial cell binding, focal adhesion formation, cell spreading, and complex changes in cytoskeleton. The attachment and growth of cells is the k
Author Contributions
CT-T revised the current literature on QCM-D and wrote the main text. IC summarized the state of the art focused on application of QCM-D in cytoskeleton changes analysis. GC revised the manuscript discussing the future trends of QCM-D applications. frontiersin.org
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. frontiersin.org
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