Kinetic amplification of enzyme discrimination.


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PDF Kinetic amplification of enzyme discrimination

Many enzyme systems discriminate with remar- kable efficiency between their substrate and clo- sely related molecules It is generally accepted that this 

PDF Kinetic Proofreading can Enhance Single Nucleotide Discrimination

26 août 2023 · Kinetic Proofreading can Enhance Single Nucleotide Discrimination in a Non-enzymatic DNA Strand Kinetic amplification of enzyme discrimination 

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The dependence of the accuracy of enzymatic systems on the mechanism of the catalyzed reaction is investigated, using a probabilistic approach. Certain mechanisms of reaction, involving a delay in one of the steps act as kinetic amplifiers of molecular discriminations.
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