Harmonizing SUVs in multicentre trials when using different

Does collaboration undermine the goal of a multicenter trial?
It undermines the goal of a multicenter trial of having enough participants to answer a question and, perhaps more importantly, the trust among investigators. Academic institutions have taken a strong stand against this principle of collaboration and in defense of academic freedom for each investigator.
Are multicentre trials more effective than single centre trials?
Results Single centre trials showed larger intervention effects than did multicentre trials (combined difference in standardised mean differences −0.09, 95% confidence interval −0.17 to −0.01, P=0.04), with low heterogeneity across individual meta-analyses (I 2 =0%, between meta-analyses variance τ 2 =0.00).
Are there exceptions to a multicenter trial?
However, there are exceptions, as discussed in Chapter 21. The multicenter trial is an important research tool. More, not fewer, are needed to address a variety of treatment questions. It is ironic in view of this fact that present-day reward and incentive systems tend to favor single-center over multicenter trials.
Can arbitrary sample sizes be determined in multi-centre trials?
We propose a sample size determination procedure for multi-centre trials comparing two treatment groups for a continuous outcome, modelling centre differences using random effects and allowing for arbitrary sample sizes. It is assumed that block randomisation with fixed block length is used at each study site for subject allocation.

Patient Population

During 6 months, 52 patients referred to our institution for staging or restaging of a NSCLC were included in this study. The study was approved by the local Ethics Committee (ref A12-D24-VOL13, Comité de protection des personnes Nord Ouest III) waiving signed informed consent. Among these patients, ten underwent two PET examinations for the purpos

Calibration and Cross-Calibration of The Pet System

The calibration of the PET system was performed daily with a 68Ge cylinder with a known radioactive concentration. This cross-calibration procedure was performed twice during the present study. A solution of 18F-FDG (70.6 and 70.5 MBq, as assessed by the dose calibrator) was introduced into a cylindrical phantom with an exactly known volume and com

Phantom Preparation

The phantom set is the International Electrotechnical Commission body phantom set, which consists of a torso cavity containing a 5-cm-diameter cylindrical insert filled with foam pellets with an average density of 0.30 g/ml positioned in the centre of the phantom to simulate lung tissue and six coaxial isocentred spheres with internal diameters of

Patient Studies

The weight and height of patients on the day of the PET examination were recorded. BMI was computed as follows and was used to separate overweight (BMI > 25 to < 30 kg/m2) and obese patients (BMI ≥ 30 kg/m2) from low to normal weight patients (BMI < 25 kg/m2): After a 15-min rest in a warm room, patients who had been fasting for 6 h were injected w

PET/CT Acquisition and Reconstruction Parameters

All PET imaging studies were performed on a Biograph TrueV (Siemens Medical Solutions) with a 6-slice spiral CT component. The technical and performance characteristics of the PET component of the TrueV system can be found elsewhere [26]. CT acquisition was performed first, with the following parameters: 60 mAs, 130 kVp, pitch 1 and 6 × 2 mm collim

PET/CT Analysis

Phantom studies Activity concentration RCs as a function of sphere (tumour) size were measured. RCs are defined as the ratio between measured and true activity concentration in a sphere. For that purpose, 3-D 50 % isocontour VOIs were drawn over each sphere for each set of reconstructed data and maximum and mean pixel values were recorded. Patient analysis The same reader (CL) analysed all PET data sets to extract PET quantitative values for OSEM and PSF reconstructions. Regions of interest (ROIs) were drawn over primary tumour lesions, mediastinal and hilar nodes considered to have pathologically increased uptake and metastatic lesions. ROIs were drawn on the axial slice on which lesions displayed the highest 18F-FDG uptake, by means of a 50 % isocontour method. The mean and maximum pixel values were extracted from each ROI and mean and maximu

Statistical Analysis

The first step of the analysis was to determine the optimal filter settings for PSF reconstruction to meet EANM harmonizing standards. For that purpose, for all sets of reconstructed data, RCs for all spheres were compared to EANM expected values by means of the root mean square error (RMSE) method. The kernel size that minimizes the RMSE when comp

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PDF	Harmonizing SUVs in multicentre trials when using different 6 avr 2013 · Abstract Purpose We prospectively evaluated whether a strategy using point spread function (PSF) reconstruction for both diagnostic and

PDF	Harmonizing FDG PET quantification while - ResearchGate PET) to harmonize SUVs across different PET systems interpretation with harmonized SUV results This prospective multicentre trial sought to validate the

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PDF	Harmonizing FDG PET quantification while - SpringerLink 30 juil 2015 · PET) to harmonize SUVs across different PET systems independent of the so that their data is comparable to other centres with older systems This issue SUV results This prospective multicentre trial sought to validate the

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