EPHA4 is a disease modifier of amyotrophic lateral sclerosis in - France

What is amyotrophic lateral sclerosis (ALS)?
Amyotrophic lateral sclerosis (ALS) is a fatal motor neurone disease (MND) characterized by symptoms of degeneration of the upper motor neurons (UMNs) in the motor cortex as well as the lower motor neurons (LMNs) in the spinal cord and brain stem.
Is ALS a disease modifying disease?
As with all major neurodegenerative disorders, development of disease-modifying therapies has proven challenging for multiple reasons. Nevertheless, ALS is one of the few neurodegenerative diseases for which disease-modifying therapies are approved.
Is amyotrophic lateral sclerosis a risk factor for neurodegeneration?
Amyotrophic lateral sclerosis (ALS), with a lifetime risk of ~1/350, represents an area of huge unmet need and is a useful model of neurodegeneration, with measurable changes in motor function over a relatively short time frame.
Is EphA4 a disease modifier of amyotrophic lateral sclerosis?
Van Hoecke A, Schoonaert L, Lemmens R, et al. EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans. Nat Med 2012 ;18: 1418 - 1422 34. Al-Chalabi A, Calvo A, Chio A, et al. Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study. Lancet Neurol 2014 ;13: 1108 - 1113

PDF	EPHA4 is a disease modifier of amyotrophic lateral sclerosis in ALS in order to identify genes of which the knockdown rescued the phenotype disease severity and thus that EphA4 is a modifier of ALS in animal models ...

PDF	Protocole National de Diagnostic de et de Soins (PNDS) Filière 16 déc. 2021 Génétique de la Sclérose Latérale Amyotrophique ... disease modifier of amyotrophic lateral sclerosis in animal models and in humans.

PDF	Étude des “ Topologically Associated Domains (TADs) ” dans les 3 nov. 2017 teaching and research institutions in France or ... EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in.

PDF	Epidémiologie de la sclérose latérale amyotrophique: Facteurs de 12 nov. 2015 La sclérose latérale amyotrophique (SLA) ou maladie de Charcot ... EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal.

PDF	Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway 9 nov. 2020 teaching and research institutions in France or ... EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models.

PDF	Zebrafish models of human motor neuron diseases: Advantages and Motor neuron diseases. Zebrafish. Upper and lower motor neurons. Hereditary spastic paraplegia. Amyotrophic lateral sclerosis. Spinal muscular atrophy.

PDF	The multifaceted role of kinases in amyotrophic lateral sclerosis Amyotrophic lateral sclerosis is the most common degenerative disorder of motor EphA4-LBD ... as an ALS-causing gene and/or a disease modifier (Cirulli.

PDF	Novel aspects of TDP-43s interaction with ALS-related autophagy 12 févr. 2021 Screening tests conducted on ALS zebrafish models permitted identification of genetic modifiers of the disease such as EphA4 (Van Hoecke et ...

PDF	What do we know about the variability in survival of patients with 18 juin 2020 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenera- tive disease defined by the presence of muscle weakness and the progressive death ...

PDF	Genetic factors for survival in amyotrophic lateral sclerosis: an to be associated with a risk of ALS [4]. Some of them also were reported to have a disease modification effect which means they are always linked to a

Share on Facebook Share on Whatsapp

Choose PDF

More..

PDF	EPHA4 is a disease modifier of amyotrophic lateral sclerosis in All these data suggest that low expression of EphA4 attenuates disease severity, and thus that EphA4 is a modifier of ALS in animal models and patients The

PDF	La Fondation Thierry Latran - Edimark 9 nov 2013 · France, elle est régie par des instances de décision et de de la SLA (European Network to Cure ALS [ENCALS]) Entre 2008 et 2013,

PDF	Final report - CORDIS disease-modifying pathways to pave the way for novel therapies in Amyotrophic Lateral Sclerosis (ALS) To achieve this goal large-scale quantitative data sets

PDF

PGC-1a is a male-specific disease modifier of human and

12 mai 2013 · Université de Strasbourg, UMRS1118, Strasbourg F-67085, France Amyotrophic lateral sclerosis (ALS) is a devastating, adult-onset neurodegenerative disorder of the PGC-1a as a genetic disease modifier in two independent (2012) EPHA4 is a disease modifier of amyotrophic lateral sclerosis in

PDF	State of play in amyotrophic lateral sclerosis genetics - Demystifying 26 déc 2013 · neurodegenerative diseases, ~10 of ALS is classified as familial, whereas the lateral sclerosis and frontotemporal lobar degeneration in France EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal

PDF

Fishing for causes and cures of motor neuron disorders - Disease

amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP) CHU Pitié-Salpétrière, 75013 Paris, France *Author for a protective modifier of SMA (Oprea et al , 2008), rescued the zebrafish knockdown EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans Nat