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  • Can aspirin cause poisoning?

    (See also Overview of Poisoning .) Ingestion of aspirin and similar drugs (salicylates) can lead to rapid (acute) poisoning due to an overdose. The dose necessary to cause acute poisoning, however, is quite large. A person weighing about 150 pounds would have to consume more than thirty 325-milligram aspirin tablets to develop even mild poisoning.

  • Can aspirin poisoning cause hypoventilation?

    Aspirin poisoning causes hyperventilation which helps to maintain alkalemia. Beware! Giving sedatives may lead to hypoventilation and worsen aspirin poisoning. Paralysis and endotracheal intubation may be a lethal procedure!

  • What are therapeutic drug levels for aspirin?

    Therapeutic drug levels for aspirin are 150 to 300 mcg/mL (salicylate). Plasma levels of aspirin can range from 3 to 10 mg/dL for therapeutic doses to as high as 70 to 140 mg/dL for acute toxicity.

  • How does activated charcoal affect aspirin absorption?

    Activated charcoal is given as soon as possible and reduces aspirin absorption. For moderate or severe poisoning, fluids containing sodium bicarbonate are given by vein. Unless there is kidney damage, potassium is added to the fluid. This mixture moves aspirin from the bloodstream into the urine.

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