lyme disease test elisa


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  • Do high Elisa index values predict Lyme disease?

    Using a Lyme enzyme-linked immunosorbent assay (ELISA), we demonstrated that high ELISA index values are strongly predictive of Lyme disease.

  • What is two-tiered Lyme disease testing?

    Two-tiered Lyme disease testing uses two tests. The first is a screening test that should detect anyone who might have the disease. Tests that do this well have are regarded as having high sensitivity. This test is followed by a second test that is intended to make sure that only people with the disease are diagnosed.

  • What ELISA test should be performed if my child has Lyme disease?

    For children with a Lyme ELISA index value between 1.0 and 2.9 and a clinical presentation compatible with Lyme disease, supplemental Western immunoblot testing should still be performed.

  • What is the best test for Lyme disease?

    Direct tests lack sensitivity for Lyme disease; hence, serologic tests remain the gold standard. Currently recommended is a standard 2-tier testing strategy using an enzyme-linked immunosorbent assay (ELISA) followed by Western blot for confirmation. A number of factors limit the sensitivity of direct culture for diagnosing Lyme disease.

The First Test: Elisa

This blood test is for antibodies against the Lyme disease bacteria. Because it can take some time for your body to produce antibodies, this test isn’t always accurate soon after a person is infected. lyme.health.harvard.edu

The Second Test: Western Blot Or A Second Elisa

There are two options for the second test. One is called a Western blot, which looks at how your antibodies react to specific parts of the Lyme disease bacteria. The Western blot test has been part of the two-step testing system since 1994 and is more commonly used. The other option is to do a second ELISA test, which measures antibodies to a speci

A Possible Drawback of The Two-Step Testing System

The CDC testing guidelines recommend a second test only if the first test is positive or unclear. Because the first test may not pick up antibodies soon after possible exposure to the Lyme disease bacteria, that means a person with Lyme disease may never get the second test. So, if your ELISA test is negative, you may want to ask your doctor to rep

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