recent guidelines for tuberculosis treatment


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PDF Updated WHO consolidated guidelines on DR-TB treatment 2022

4 avr 2023 · Guidelines and derivative documents on TB treatment: Guidelines and handbooks 2020 Page 3 New developments in 2022: Guidelines Handbooks

  • WHO guidelines for treatment of tuberculosis?

    This document includes two new recommendations – one for the use of a 6-month BPaLM regimen, composed of bedaquiline, pretomanid, linezolid and moxifloxacin in patients with multidrug-resistant or rifampicin resistant TB (MDR/RR-TB) and those with additional resistance to fluoroquinolones (pre-XDR-TB) and another for a

  • The MDR-TB medication regimen consists of at least four drugs in the intensive phase: three drugs from group A [linezolid, bedaquiline (BDQ) and moxifloxacin/levofloxacin] and one drug from group B (clofazimine, or terizidone/cycloserine) [29].

  • What is the latest treatment for tuberculosis?

    Pretomanid has been added to facilitate the implementation of the six-month regimen for treatment of MDR/RR-TB, which was recommended by WHO in December 2022 and is composed of bedaquiline, pretomanid and linezolid, with or without moxifloxacin (BPaLM/BPaL).

  • What is the current treatment protocol for tuberculosis?

    Drug therapy
    For initial empiric treatment of TB, start patients on a 4-drug regimen: isoniazid, rifampin, pyrazinamide, and ethambutol.
    Once the TB isolate is known to be fully susceptible, ethambutol can be discontinued.

  • The 2022 update contains two new recommendations (based on a review of new evidence) regarding treatment regimens for MDR/RR-TB: (i) the use of the 6-month treatment regimen composed of bedaquiline, pretomanid, linezolid (600 mg) and moxifloxacin (BPaLM) rather than the 9-month or longer (18-month) regimens in MDR/RR-
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