anticorps anti thyroperoxydase in english

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WHO International Standard 1 INTENDED USE

1 INTENDED USE The 1st International Standard for anti-thyroid peroxidase antibodies coded 19/260 is intended for use in the calibration of immunoassays for anti-thyroid peroxidase It replaces the NIBSC Reference Reagent (NRR) coded 66/387 for anti-thyroid microsome serum which was produced in the 1960\'s as a research reagent for anti

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Monoclonal Mouse Anti-Human Thyroid Peroxidase Clone MoAb47

For in vitro diagnostic use Monoclonal Mouse Anti-Human Thyroid Peroxidase (TPO) Clone MoAb47 is intended for use in immunohistochemistry (IHC) The antibody labels thyroid peroxidase-expressing cells and is a useful aid in classification of benign and malignant thyroid tumors (1-3) Differential classification is aided by the results from a

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Thyroperoxidase and Thyroid Autoimmunity Thyroperoxydase et

Les auto-anticorps anti-thyroperoxydase et anti-thyroglobuline sont transmis comme un trait caracteristiqu e autosomique domi nant dans des families non selectionnees pour une maladie auto immune thyroidienne 275 S Mariotti P Caturegli G Barbesino and A Pinchera Serum anti-thyroid peroxidase autoantibody in autoimmune thy roid disease

Can anti-thyroid peroxidase antibodies be detected in thyroid disease?
Anti-thyroid peroxidase (anti-TPO) antibodies in thyroid diseases, non-thyroidal illness and controls. Clinical validity of a new commercial method for detection of anti-TPO (thyroid microsomal) autoantibodies Anti-thyroid peroxidase (anti-TPO) antibodies in thyroid diseases, non-thyroidal illness and controls.
What is the NIBSC code for anti-thyroid peroxidase antibodies?
1. INTENDED USE The 1st International Standard for anti-thyroid peroxidase antibodies, coded 19/260, is intended for use in the calibration of immunoassays for anti-thyroid peroxidase. It replaces the NIBSC Reference Reagent, coded 66/387, for anti-thyroid microsome serum, produced in the 1960’s.
What is thyroid peroxidase (TPO)?
The target for this anti-thyroid microsome autoimmunity has since been identified as thyroid peroxidase (TPO) [4-6], a membrane-bound enzyme that is responsible for iodine oxidation and iodination of the thyroglobulin molecule [2,6]. Autoantibodies to TPO are present in thyroid diseases such as Hashimoto’s thyroiditis and hyperthyroidism [2,3].
Is 19/260 a standard for anti-thyroid peroxidase antibodies?
It is proposed that the candidate preparation in ampoules coded 19/260 is established as the 1st International Standard for anti-Thyroid Peroxidase antibodies with an assigned content of 555 IU/amp. Laboratory 1: gave a correction to their address which has been incorporated.

Data and Statistical Analysis

Participants were asked to return all raw assay data in electronic form for central computation at NIBSC, plus participants’ own estimates of activity as calculated by the method normally used in their laboratory. cdn.who.int

REPORT

A preliminary report will be prepared and circulated to all participants for comment before submission to the Expert Committee on Biological Standardisation of WHO. In the report, participating laboratories will be identified by a laboratory number only and any requests to treat information in confidence will be respected. cdn.who.int

3. UNITAGE

Each ampoule of the International Standard contains antibodies. cdn.who.int

6. DIRECTIONS FOR OPENING

DIN ampoules have an “easy-open” coloured stress point, where the narrow ampoule stem joins the wider ampoule body. Tap the ampoule gently to collect the material at the bottom (labelled) end. Ensure that the disposable ampoule safety breaker provided is pushed down on the stem of the ampoule and against the shoulder of the ampoule body. Hold the b

No attempt should be made to weigh out any portion of the freeze-dried material prior to

reconstitution. For all practical purposes each ampoule contains the same quantity of the substances listed above. Depending on the intended use, dissolve the total contents of the ampoule in a known volume of a suitable diluent. Users should make their own investigations into the type of diluent suitable for their use. If extensive dilutions are

9. CITATION

In any circumstance where the Recipient publishes a reference to NIBSC materials, it is important that the title of the preparation and any NIBSC code number, and the name and address of NIBSC are cited correctly. cdn.who.int

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