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PDF R-BAC: Rituximab Bendamustine Cytarabine

What is R-BAC? R-BAC is the short name for this cancer treatment The 3 drugs you will receive during this treatment are Rituximab (or “R”) Bendamustine (or “B”) and Cytarabine (or “Ara-C”)

  • How effective is R-bac compared to BR?

    R-BAC was administered in a 2-day schedule or with attenuated dose in 51% of patients. Patients treated with R-BAC achieved CR in 91% of cases, as compared with 60% for BR ( p < 0.0001). The 2-year PFS was 87 ± 3% and 64 ± 7% for R-BAC and BR, respectively ( p = 0.001).

  • Is R-bac a first-line treatment for mantle cell lymphoma (MCL)?

    The R-BAC regimen is considered among standard first-line treatment for elderly fit patients with mantle cell lymphoma (MCL). In the previous R-BAC500

  • Can cytarabine be combined with B and R bac?

    In the present study we combined cytarabine with B and R (R-BAC) in previously untreated patients with MCL aged >65, and in patients relapsed or refractory (R/R) to one previous line of immunochemotherapy. This prospective safety/efficacy phase 2 study started with a dose-finding stage based on three stepwise dose-escalations of cytarabine.

  • Does R-bac increase hematological toxicity in elderly patients with MCL?

    5. Conclusions The BE vs. BAC study indicates that R-BAC, even when administered in the 2-day schedule or with attenuated dose, was associated with significantly more prolonged PFS than BR in elderly patients with previously untreated MCL. As hypothesized hematological toxicity was significantly higher for R-BAC regimen.

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