b cell malignancies review


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  • What is the most common B-cell malignancy?

    Diffuse large B-cell lymphoma (DLBCL) is the most common type of B-cell lymphoma.
    DLBCL typically affects older people and accounts for one out of three cases of non-Hodgkin lymphoma.

  • How do you diagnose B-cell malignancy?

    B-Cell Lymphoma Diagnosis
    The first step in diagnosing B-cell lymphoma is to have a physical exam and blood work followed by imaging tests.
    Imaging tests can include: Chest X-ray to see if there are enlarged lymph nodes in the chest.
    Computed tomography (CT) scan to check for lymphoma in the chest and abdomen.

  • What are the B-cell malignancies?

    A type of cancer that forms in B cells (a type of immune system cell).
    B-cell lymphomas may be either indolent (slow-growing) or aggressive (fast-growing).
    Most B-cell lymphomas are non-Hodgkin lymphomas.
    There are many different types of B-cell non-Hodgkin lymphomas.

  • B cells can promote tumor development through the production of autoantibodies and tumor growth factors.
    Regulatory B cells can directly and indirectly suppress Th1 and CD8+ cytolytic T cell responses.
    Targeting specific B cell subsets may be of therapeutic value in cancer.

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