b cell maturation activation and differentiation notes


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PDF Chapter 10 – T Cell Maturation Activation and Differentiation

The course of maturation of such a cell after it arrives in the thymus can be followed by analysis of its cell surface molecules

PDF B Cell Activation and Differentiation Lecture 11 Kuby (Chapter 11)

23 mar 2009 · creates repertoire of naïve mature B cells and T cells • B cells undergo further diversification after antigen stimulation – Class 

  • How are B cells activated in short notes?

    B cells are activated by antigen presented by MHC and co-stimulatory (CD40-CD40L) signals from Th2 cells.
    After activation, B cells undergo rounds of mutation and selection to generate high-affinity memory B cells and plasma cells.

  • What is the maturation activation differentiation of T cells?

    T cell differentiation and maturation is a tightly regulated process during which bone marrow lymphoid precursors undergo a transit from the thymic cortex to the thymic medulla leading to the elimination of those cells with a B lymphocyte potential and the removal of self-reactive thymocytes (recognizing self-antigens)

  • The mature B cell that moves into the periphery can be activated by antigen and become an antibody-secreting plasma cell or a memory B cell which will respond more quickly to a second exposure to antigen.
    B cells which fail to successfully complete B cell development undergo apoptosis (programmed cell death).

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