b cell maturation review
Some BCR signals, such as those initiated by Syk and the cytoplasmic tail of Igα, are required for both B-cell development and peripheral maturation.
Other signalling functions, such as those mediated by Btk and the cytosolic tail of Igβ, are required only at selected checkpoints.
What is B cell maturation?
Developing B cells move toward the center of the marrow as they mature.
Mature naive B cells leave the marrow and use selectins to bind addressins on blood vessel endothelium to enter peripheral lymphoid tissues, passing through T cell areas and entering the B cell areas (follicles).
What makes B cells mature?
B cell development starts in the bone marrow (BM) and continues in the spleen to final maturation.
Developmental progression is guided by sequential events leading to assembly, expression, and signaling of the B cell antigen receptor (BCR).
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