carboxylic acid derivatives synthesis practice problems


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PDF Practice Problems on Carboxylic Acid Derivatives -‐ Ans

Practice Problems on Carboxylic Acid Derivatives -‐ Ans For each of the following reaction provide the necessary reagents for the synthesis in good yield Provide the product(s) from each of the synthesis shown below OH 2) LiCu(CH2CH3)2 3) acid workup

PDF Carboxylic Acids and Derivatives – Synthesis Problems

Carboxylic Acids and Derivatives – Synthesis Problems a H b c d e f i j k l m n o O O O O OO Br H3CHN NHCH3 Cl O N OH NH 2 OH NH2 OH NH2

  • Can carboxylic acid derivatives be synthesized?

    In this chapter we learn that all of the carboxylic acid derivatives can be synthesized from carboxylic acids. These reactions tend to be more useful for multiple-step syntheses to build large and complex molecules. The carboxylic acid derivatives along can be hydrolyzed to produce carboxylic acids.

  • Are esters functional derivatives of carboxylic acids?

    Esters are considered to be functional derivatives of carboxylic acids in which the acidic proton has been replaced by an organic group. The synthesis of esters by the acid catalyzed condensation of a carboxylic acid and an alcohol was considered at the end of the previous chapter.

  • Which is the most reactive derivative of carboxylic acid?

    Ans: Acid chloride is the most reactive derivative of carboxylic acid. The halogen atom inductively withdraws electron density away from the electrophilic carbon of the carbonyl group. Thus, acid halides are very reactive towards nucleophilic attack, and nucleophilic acyl substitution reaction takes place since the chloride is a good leaving group.

  • How to reduce carboxylic acid derivatives to aldehydes?

    Since relatively few methods exist for the reduction of carboxylic acid derivatives to aldehydes, it would be useful to modify the reactivity and solubility of LAH to permit partial reductions of this kind to be achieved. The most fruitful approach to this end has been to attach alkoxy or alkyl groups on the aluminum.

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