b cell types and functions
Where does B cell development occur?
Early B cell development and commitment to the B cell lineage occurs in the foetal liver prenatally, before continuing in the bone marrow throughout life.
What are the 4 types of B cells?
There are four main B cell types: transitional, naïve, plasma, and memory cells. A transitional B cell is the link between immature B lymphocytes in the bone marrow and mature B cells in lymphoid organs. These cells have differentiated into B lymphocytes from common myeloid progenitor cells in the bone marrow; however, they are not yet mature.
What is a B cell?
The B lymphocyte (B cell) is one of the most important cells of the body. These cells form part of the adaptive immune response by producing antibodies and presenting antigens to T cells. Once activated, they can mature into plasma cells or memory B lymphocytes. This article covers B cell development and subtypes.
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B Cell Responses: Cell Interaction Dynamics and Decisions
18 avr. 2019 The initial cell types that handle incoming antigens differs between the lymphoid tissue ... functions beyond providing help to B cells. |
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Cell-intrinsic functions of the transcription factor Bhlhe40 in activated
12 mars 2021 Although the molecular programs regulated by Bcl6 in GC B cells and TFH cells are very different 15 in both cell types it functions in part ... |
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YY1 plays an essential role at all stages of B-cell differentiation
22 juin 2016 Unlike wild-type pro-B cells YY1-deficient pro-B ... important in basic cellular functions |
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Immunoglobulin profile and B-cell frequencies are altered with
24 oct. 2019 B-cell function was tested in whole blood PBMC's and as isolated ... types may contribute significantly to the function of a cell type of ... |
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In Immune Counter-Regulation Nonredundant Roles for B Cell
role of B cell-derived IL-10 in infectious and inflammatory disease and underscore the utility of cell type-specific knockouts for. |
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B cell-specific XIST complex enforces X-inactivation and restrains
1 avr. 2021 in adult human B cells to silence a subset of X-linked immune genes such as TLR7. ... cell-type-specific diversification and function for ... |
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Transcription factors regulating b-cell function
Type 2 diabetes is primarily associated with insulin resistance and b-cell dysfunction. Maintenance of functional mature b-cells is imperative for ensuring |
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PON2 subverts metabolic gatekeeper functions in B cells to promote
2 févr. 2021 Unlike other cell types developing B cells undergo multiple rounds of somatic recombination and hypermutation to evolve high-. |
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Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic
13 sept. 2012 b cell proliferation with adaptive b cell function. We ... The pathogenesis of b cell dysfunction in type 2 diabetes. |
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Identification of the Human Mature B Cell miRNome
22 mai 2009 dant expression in a few cell types many tissue- specific miRNAs remain unrevealed. To understand the role of miRNAs in B cell function and ... |
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Differentiation of memory B and T cells - Dr José Mordoh
function The B-cell response and development of humoral memory to thymus (T )-dependent antigens during an infection (e g IL-12 [60,61 ], type-I interferon |
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B Lymphocytes - EOLSS
These two cell types, although they have much in common, function in fundamentally different ways The major role of B cells is to produce antibody molecules |
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B-Cell Development, Activation, and Differentiation - Roswell Park
13 nov 2014 · During early stages of B cell development, functional rearrangements of B cell activation • Two major types: T cell dependent (TD) and T cell |
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Antibody-independent B cell effector functions in - UT Southwestern
B cells possess a variety of antibody-independent effector functions that have the capacity to influence T cell responses B cells can serve as antigen presenting cells (APC) to CD4 þ T cells B cell APC function is particularly effective when B cells recognize their cognate antigen with the B cell receptor (BCR) |
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Review Article B Lymphocytes: Development - Hindawicom
6 août 2013 · In this paper, we describe B lymphocyte functions in autoimmunity heavy chain types (IgM, IgD, IgG1–4, IgA1-2, and IgE) are located on |
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Signalling mechanisms in B cell differentiation
The two major types of lymphocytes are B cells and T cells, but other cells like cytokines for recruiting inflammatory cells and they can also function as antigen |
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THE DARK SIDE OF B-CELL DIFFERENTIATION - Louis M Staudt
response functions normally, the clonal expansion of B cells is Diffuse large B- cell lymphoma (DLBCL) is the most common type of NHL (30–40 of cases) |
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B Cells, Antibodies, and More - CJASN
11 jan 2016 · kidney disease and transplant rejection Antibody Types Because a principal function of B lymphocytes is anti- body production, it is important |
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