acid hydrolysis of amide chemguide


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  • How do you reduce amides in Chemguide?

    The reduction of amides
    Amides can be reduced to primary amines by reaction with lithium tetrahydridoaluminate, LiAlH4, in dry ether (ethoxyethane) at room temperature.
    The initial reaction is followed by treatment with dilute acid, such as dilute sulphuric or hydrochloric acid.

  • Do amides react with HCL?

    In the presence of a strong acid, such as HCl, an amide reacts with water to produce a carboxylic acid and an ammonium or amine salt.
    In the presence of a strong base, like NaOH, the amide reacts to produce ammonia or an amine, and a carboxylic acid salt.

  • What is the acidic hydrolysis of amide?

    Hydrolysis of Amide
    In an acidic medium, amide interacts with the water molecule to give a carboxylic acid and the salt of ammonia or amine salt.
    In a basic medium, amide interacts with the water molecule to give a carboxylic acid and the salt of ammonia or amine salt.

  • The reversibility of this reaction means that an amide can hydrolyze to form an amine and a carboxylic acid.
    This reaction is reversible exergonic.

Hydrolysis under acidic conditions Taking ethanamide as a typical amide: If ethanamide is heated with a dilute acid (such as dilute hydrochloric acid), ethanoic acid is formed together with ammonium ions. So, if you were using hydrochloric acid, the final solution would contain ammonium chloride and ethanoic acid.
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