ceftriaxone coverage

Ceftriaxone Antibiotic Class: Third-Generation Cephalosporin Antimicrobial Spectrum: Staphylococcus aureus (methicillin susceptible), Coagulase negative  

Ceftriaxone is reversibly bound to human plasma proteins, and the binding decreased from a value of 95 bound at plasma concentrations of

Non-ICU Patient WITH risk factors for DRSP1 B-lactam (plus) Coverage for atypical organisms Ceftriaxone 1 gm IV push/IM daily -or- Azithromycin 500 mg  

gram-negative or MRSA coverage if initial therapy has failed (d) -Dosing: Higher listed doses of cefazolin, clindamycin, cefuroxime, nafcillin and ceftriaxone

Ceftriaxone has a broad spectrum of in vitro activity and is used in neonates for treating gonococcal ophthalmia and as a second line drug for sepsis and 

If a patient is very sick or immunocompromised, it's OK to cover Gram positive coverage: 1 generation (Ceftriaxone): Good gram negative coverage except 

Pseudomonas), ceftriaxone should provide sufficient gram-negative coverage ( and Unless extended anaerobic coverage is needed, use ampicillin instead of

IV q8h for ceftriaxone (meropenem will cover listeria in patients >50 yo) Substitute TMP-SMX* 5 mg/kg IV q8h for ampicillin if Listeria coverage when

Ceftriaxone 2g IV q 12 hours PLUS • Vancomycin ADD Ampicillin 2g IV q4 hours for Listeria coverage For meningitis: Replace Ceftriaxone or Ampicillin with

cefoxitin plus doxycycline (93 ); clindamycin plus ciprofloxacin (97 ) vs ceftriaxone and doxycycline (95 ); moxifloxacin (90 ) vs ofloxacin plus metronidazole