high risk neuroblastoma study 1 of siop-europe


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PDF HIGH-RISK NEUROBLASTOMA STANDARD CLINICAL PRACTICE

conducted by the European Neuroblastoma Study Group (ENSG) between 1990 and 1999 (ENSG5) investigated the effect of dose intensity of induction therapy on EFS in patients over the age of 1 year with metastatic disease

  • Should induction therapy be randomized in high-risk neuroblastoma?

    To our knowledge, this is only the fourth randomized study of induction therapy in high-risk neuroblastoma.3,12,31 Randomized comparisons have many advantages as they mitigate many of the differences in supportive care and assessment that change over time. When designing the trial, one option was to compare the current Children s

  • What percentage of neuroblastoma patients have high-risk disease?

    Patients with high-risk disease account for approximately half of all patients with newly diagnosed neuroblastoma.

  • How is high-risk neuroblastoma treated?

    Kletzel M, Katzenstein HM, Haut PR, et al. Treatment of high-risk neuroblastoma with triple-tandem high-dose therapy and stem-cell rescue: results of the Chicago Pilot II Study. J Clin Oncol 2002;20:2284-2292.

  • Does risk stratification improve neuroblastoma outcomes?

    Prospective studies of risk stratification and risk-adapted therapy have sustained the excellent outcomes in patients with low-risk and intermediate-risk neuroblastoma while also reducing the incidence of adverse events; improved outcomes have also been achieved in those with high-risk disease.

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