acylation of amines with acetic anhydride


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PDF An Efficient Method for Acylation Reactions

The base catalyzed acylation of alcohols phenols amines and thiols by acid anhydride or acyl chloride is an established procedure in organic synthesis

  • When an amine reacts with an anhydride?

    The reaction of an anhydride and an amine form an amide through nucleophilic acyl substitution.
    During this reaction three changes in bonding occur.
    The leaving group is removed from the anhydride.
    The amine loses a hydrogen.

  • Acylation of Amines
    Ammonia, 1o amines, and 2o amines react rapidly with acid chlorides or acid anhydrides to form 1o, 2o, and 3o amides respectively (Sections 21-4 and 21.5).

  • What happens when amine reacts with acetic anhydride?

    Acid Anhydrides React with Amines to Form Amides.22 jan. 2023

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