benefits of therapeutic drug monitoring of vancomycin a systematic review and meta analysis

What are the benefits of therapeutic drug monitoring of vancomycin?

Background.
Therapeutic drug monitoring (TDM) has proven effectiveness in maintaining efficacy and reducing toxicities associated with vancomycin.
A trough level of (15–20 mg/L) for MRSA serious infections is recommended.

What are the benefits of therapeutic drug monitoring?

This helps your provider figure out the most effective dose for you.
Once that dose is determined, you may be tested regularly to make sure the medicine is still effective without being harmful.
You may also need testing if you have symptoms of a serious side effect.
Side effects vary depending on the medicine.

Why does vancomycin need to be monitored?

Vancomycin can also be given before certain surgeries to prevent an infection.
Monitoring the level of vancomycin is important because its effectiveness relies on keeping blood levels above a minimum concentration for the entire duration of therapy (also referred to as total drug exposure).

Vancomycin, a broad-spectrum glycopeptidic antibiotic against Gram-positive bacteria, remains one of the most important antibiotics because of its ability to inhibit methicillin-resistant Staphylococcus aureus (MRSA),¹¹³ a virulent and highly contagious pathogen spreading in hospitals and communities.