amide hydrolysis under acidic conditions


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PDF Lecture 6: Hydrolysis Reactions of Esters and Amides

Simple alkyl esters such as methyl and ethyl esters are hydrolysed under acidic conditions in a reaction mechanism that is described as an AAC2 reaction: the 

PDF Acidic and Basic Amide Hydrolysis //

characterises the response of the reaction rate to changing acid conditions and its values are approximately the same for a series of compounds and may be

PDF Chapter 6 Amines and Amides

Unlike amines amides are not basic • Amide hydrolysis can take place under acidic or Hydrolysis of amides under acidic and basic conditions amide

  • Dilute acid hydrolysis occurs at concentration of 0.3%–2.5% (wt./wt.) at high temperature around 120°C–210°C, while concentrated acid hydrolysis happens with concentration of 41%–86% and low temperature of around 25°C–70°C [81].

  • What are the conditions for amide bond hydrolysis?

    Amides can be hydrolyzed into a carboxylic acid and ammonia or an amine by heating in an acidic or basic aqueous solution.
    In both cases, acid-base reactions occurring with the products make the overall reaction irreversible.

  • How does amide hydrolysis under acidic conditions?

    Hydrolysis of Amide
    In an acidic medium, amide interacts with the water molecule to give a carboxylic acid and the salt of ammonia or amine salt.
    In a basic medium, amide interacts with the water molecule to give a carboxylic acid and the salt of ammonia or amine salt.

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