dextrose 5% in 0.45 normal saline tonicity


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  • Is dextrose 5% in water hypertonic or hypotonic?

    Each 100 mL of 5% Dextrose and 0.45% Sodium Chloride Injection, USP contains dextrose, hydrous 5 g and sodium chloride 0.45 g in water for injection.
    Electrolytes per 1000 mL: sodium (Na+), 77 mEq; chloride (Cl–) 77 mEq.
    The osmolarity is 406 mOsmol/L (calc.), which is hypertonic.

  • Is dextrose normal saline isotonic or hypertonic?

    D5W (dextrose 5% in water) is a crystalloid isotonic IV fluid with a serum osmolality of 252 mOsm/L.
    D5W is initially an isotonic solution and provides free water when dextrose is metabolized (making it a hypotonic solution), expanding the ECF and the ICF.21 jan. 2024

  • What is the tonicity of dextrose?

    Dextrose 5% in Water (D5W)
    The dextrose in the solution makes its initial tonicity similar to intravascular fluid making it isotonic.
    However, once in the body, the dextrose is rapidly metabolized, leaving no osmotically active particles in the plasma and thus, it can be classified as hypotonic.

Hypotonic saline (such as 0.18−0.3% NaCl with dextrose) is commonly used as maintenance fluid in the management of acute infections. In recent years there have  Background · Results · Authors' conclusions · Characteristics of excluded Autres questions
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