hla b27 negative psoriatic arthritis


HL-A27 in Reiter's syndrome and psoriatic arthritis; a genetic factor in disease susceptibility and expression. J Rheumatol 1974; 1: 263-8. 4 Dausset J, 
  • Can HLA-B27 be negative still have psoriatic arthritis?

    Negative HLA-B27 had a tendency to correlate with hands and wrists arthritis (p=0,07) (Table 2). There was no significant association between HLA-B27 and race, psoriasis' physical symptoms, extra articular manifestations and none specific skin or joint involvement (except for hands and wrists).
  • Is HLA-B27 related to psoriatic arthritis?

    HLA-B27 is associated with the pustular form of psoriasis and weakly associated with peripheral psoriatic arthritis. In the presence of spondylitis-associated with psoriasis, 60-70% of these cases are HLA-B27 positive.
  • What if your HLA-B27 is negative?

    A negative result means you don't have HLA-B27 in your blood. A positive result means HLA-B27 was found in your blood. You may have a higher-than-average risk of certain autoimmune diseases, such as ankylosing spondylitis and reactive arthritis.
  • A positive test for HLA-B27 could bias the diagnostic process toward attributing back pain to spondyloarthritis. Conversely, a negative test for HLA-B27 could unconsciously bias a clinician against making a diagnosis of spondyloarthritis for a patient with mild, chronic back pain.
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