pka of acetic anhydride


What is the pKa constant of acetic acid?

    For acetic acid (CH 3 COOH), the Ka constant is 0.0000158 (= 10 -4.8 ); however, the pKa constant is 4.8, a more easy formula. Furthermore, the stronger the acid, the lower the pKa value. Lactic acid, for example, has a pKa value of roughly 3.8, indicating that it is a stronger acid than acetic acid.

How does acetic anhydride affect the stability of a compound?

    Acylation may improve the stability of a compound by protecting unstable groups, and may increase volatility. Acetic anhydride can be used with a basic catalyst, such as pyridine. This combination promotes smooth reactions and has great solvent power. Pyridine acts as an acceptor for the acid by-product formed in the reaction.

What is the difference between pyridine and acetic anhydride?

    Acetic anhydride can be used with a basic catalyst, such as pyridine. This combination promotes smooth reactions and has great solvent power. Pyridine acts as an acceptor for the acid by-product formed in the reaction. Pyridine may also react with acetic anhydride, however, forming N-acetyl- 1,2-dihydro-2-pyridylacetic acid. Features/Benefits

How do you dissolve acetic anhydride in chloroform?

    General Procedure 1. Dissolve 5mg sample in 5mL chloroform. 2. Add 0.5mL acetic anhydride and 1 mL acetic acid. Heat at 50°C for 2-16 hours. 3. Remove excess reagent by evaporating the mixture to dryness and redissolve the residue in chloroform for analysis by GC.
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