23 déc 2016 · SCCS/1576/16 Final version of the Opinion on Vitamin A (Retinol, Retinyl Acetate and Retinyl Palmitate) and corrigendum
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compounds including retinol, retinyl palmitate, retinyl acetate, retinyl linoleate and retinal Vitamin A is a lipophilic-soluble vitamin and as such a micronutrient
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(4) SCCS/1576/16 European Commission Health and Food Safety, cited from Serri and Iorizzo, 2008 * Retinol not used in sunscreen products and not used on
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14 nov 2016 · The SCCS has estimated that exposure to Vitamin A (retinol, retinyl palmitate, and retinyl acetate) and via body lotion at the maximum
Opinion of the Scientific Committee on Consumer Safety SCCS Final version of the Opinion on Vitamin A retinol retinyl acetate and retinyl palmitate in cosmetic products
Retinol and Retinyl Palmitate Retinol, Retinoic Acid, and Retinyl Esters a reference to the Scientific Committee on Consumer Safety (SCCS) Opinion on HC
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(SCCs) We examined the metabolism of[3H]retinol in normal human cell strains and SCC have previously been detected in skin are retinol, retinyl esters,
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the novel compound acyclic retinoid (ACR) in human hep- atoma cell lines SCCs INTRODUCTION Retinoids, a group of structural and functional analogues
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to tumor progression: Nfe2l2 response, retinol metabolism, and hedgehog signaling expresser SCCs would be resistant to retinoids [70], a family of drugs
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6 oct. 2016 (3). Does the SCCS have any further scientific concerns with regard to the use of Vitamin A. (retinol retinyl palmitate
10 déc. 2021 Keywords: SCCS revision
compounds including retinol retinyl palmitate
24 mars 2017 Vitamin A. (Retinol Retinyl Acetate
https://ec.europa.eu/health/document/download/f1881bcd-ee58-4d42-9701-3feaaa26de61_en
8 mars 2021 SCIENTIFIC COMMITTEE ON CONSUMER SAFETY (SCCS). Request for a revision of the scientific Opinion (SCCS/1576/16) on Vitamin A (Retinol.
https://health.ec.europa.eu/system/files/2021-08/sccs_o_199_0.pdf
SAFETY EVALUATION OF COSMETIC INGREDIENTS AS APPLIED BY THE SCCS . the somatotropic axis the retinoid signalling pathway
SAFETY EVALUATION OF COSMETIC INGREDIENTS AS APPLIED BY THE SCCS . the somatotropic axis the retinoid signalling pathway
22 août 2012 The Scientific Committee for Consumer Safety's (SCCS) Notes of Guidance for the Testing of. Cosmetic Ingredients was used to estimate the ...
The SCCS is of the opinion that vitamin A in cosmetics at the concentrations of 0 05 Retinol Equivalent (RE) in body lotion and 0 3 RE for other leave-on and rinse-off products is safe Regarding the contribution from cosmetics to overall/total exposure no conclusion can be drawn due to inconsistencies in the presented model calculations
Overall SCCS conclusion on eye irritation Under the conditions of the in vivostudy retinol (tested as a formulation) is a moderate irritant to the rabbit eye and retinyl acetate and retinyl palmitate (tested either undiluted or as a 30 dilution) are slightly irritating to the rabbit eye
Evaluation by the SCCS” is a document compiled by the members of the Scientific Committee on Consumer Safety (SCCS replacing the former SCCP SCCNFP and SCC) The document contains relevant information on the different aspects of testing and safety evaluation of cosmetic substances in Europe The emphasis of this guidance is on
Is there any information for the determination of impurities for retinol?
No information for the determination of impurities was provided for retinol, retinyl acetate or retinyl palmitate.
What do we know about skin absorption studies of retinoids?
Relevant toxicity studies Absorption Skin GI tractus Only limited skin absorption studies for retinoids have been conducted (including ROL and RAL), and the systemic bioavailability is not well understood (Yourick et al., 2008). Although both in vivoand in vitrodata demonstrate that substantial levels
What is the retinol concentration in the liver?
concentration of 20?g retinol/g liver (0.07 ?mol/g) in adults represents a level assumed to maintain adequate plasma retinol concentration, to prevent clinical signs of deficiency and to provide adequate stores.
What is the molecular weight of retinol?
Reference: 40 In plasma, retinol circulates bound to retinol-binding protein (RBP or RBP4; molecular weight - MW -, 24 kDa), the specific vitamin A carrier protein synthetised mainly by the liver, which in turn forms a high MW complex with transthyretin (TTR, 55 kDa).
Opinion of the Scientific Committee on Consumer Safety on o