What is the synthesis of sulfanilamide?
The synthesis of sulfanilamide (a sulfa drug) illustrates how the reactivity of aniline can be modified to make possible an electrophilic aromatic substitution. The corresponding acetanilide undergoes chlorosulfonation.
How is sulphanilamide prepared?
Sulphanilamide can be prepared by the reaction of P-acetamido benzene sulphanilamide with Hydrochloric acid or ammonium carbonate. The acetamido groups are easily undergo acid catalysed hydrolysis reaction to form p-amino benzene sulphonamide.
What is the history of sulfonamides?
History of Sulfonamides. Sulfonamides or “sulfa” drugs are synthetic antimicrobial agents that were discovered in the 1930s. In 1932, Domagk, a scientist working at Bayer in Germany on methods to stain pathogenic bacteria, found the red dye, Prontosil, cured streptococcal infections in mice, but was ineffective in cell culture.
How to synthesis and submit sulphanilamide from P-acetamido benzene?
To synthesis and submit sulphanilamide from p-acetamido benzene sulphanilamide and calculate its percentage yield. Sulphanilamide can be prepared by the reaction of P-acetamido benzene sulphanilamide with Hydrochloric acid or ammonium carbonate.
Sulfa Antibiotics - Synthesis of Sulfanilamide INTORODUCTION