How do aliphatic amines react with nitrous acid?
Usually it is produced indirectly in a mixture of NaNO 2 and a strong acid such as HCl or H 2 SO 4 in dilute concentration, so that the H + ions will associate with the NO 2– ions in solution. Primary aliphatic amines with nitrous acid give very unstable diazonium salts which spontaneously decompose by losing N 2 to form a carbenium ion.
Can tertiary amines be acylated?
Tertiary amines cannot be acylated due to the absence of a replaceable hydrogen atom. With the much less active benzoyl chloride, acylation can still be performed by the use of excess aqueous base to facilitate the reaction. Because amines are basic, they neutralize carboxylic acids to form the corresponding ammonium carboxylate salts.
How do acyl chlorides and acid anhydrides react with amines?
Acyl chlorides and acid anhydrides react with primary and secondary amines without the presence of heat to form amides. Tertiary amines cannot be acylated due to the absence of a replaceable hydrogen atom. With the much less active benzoyl chloride, acylation can still be performed by the use of excess aqueous base to facilitate the reaction.
What happens to amine salts when heated to 200°C?
Upon heating to 200°C, the primary and secondary amine salts dehydrate to form the corresponding amides. Amines R 3 N react with strong acids such as hydroiodic acid (HI), hydrobromic acid (HBr) and hydrochloric acid (HCl) to give ammonium salts R 3 NH +. Nitrous acid with the chemical formula HNO 2 is unstable.
The Reaction of Propiolic Acid Esters with Tertiary Amines