How do you go from benzamide to benzoic acid?
Let's say our goal was to go from benzamide to benzoic acid. We just learned two ways to do that. One way to do that would be to add water and an acid. We get H3O plus and if we heat things up we know that we can hydrolyze our amide that way and give us our benzoic acid, so that's one possibility. That's acid-catalyzed amide hydrolysis.
What is the result of the hydrolysis of a simple amide?
The hydrolysis of a simple amide produces an organic acid and ammonia. Butyramide thus yields butyric acid and ammonia. The hydrolysis of an amide produces an organic acid and ammonia. Benzamide thus yields benzoic acid and ammonia.
How do you hydrolyze amide?
One way to do that would be to add water and an acid. We get H3O plus and if we heat things up we know that we can hydrolyze our amide that way and give us our benzoic acid, so that's one possibility. That's acid-catalyzed amide hydrolysis. Or we could use base.
What is the reaction between a strong base and an acid?
We have a strong base and we have an acid. We're going to have an acid-base reaction. The base is going to take a proton from the acid. Let's say these electrons in red take a proton from the acid, leave these electrons behind. Let's go ahead and draw the product. We would have the conjugate base to a carboxylic acid, which is a carboxylate anion.
Chapter 5 Carboxylic Acids and Esters