Why are decarboxylation reactions thermodynamically favorable?
Decarboxylation reactions are generally thermodynamically favorable due to the entropic factor: one molecule is converted into two, one of which is a gas - this represents an increase in disorder (entropy). Enzymatic decarboxylation steps in metabolic pathways are also generally irreversible.
What are decarboxylases?
Decarboxylases or carboxy-lyases are enzymes that aid in the decarboxylation of certain organic acids. By removing the carboxyl group (-COOH) from the amino acid, decarboxylation results in the creation of an amine.
Which decarboxylations are commonly encountered in introductory organic chemistry?
In the footnotes is a brief discussion of two more decarboxylations that are sometimes encountered in introductory organic chemistry: the Kolbe electrolysis and decarboxylation in some Diels-Alder reactions. [ note 7] 9. Conclusion Decarboxylation occurs readily in beta-keto acids and in malonic acid derivatives.
What temperature do you decarboxylate at?
I do know thc vaporizes at approximately 138 degrees so technically you would want to decarboxylate at about 130 or even 125 for I’d say 4 to 8 hours. Just a guess but this way you would have more thc and terpene. And a higher temperature like say 220 would give you more cbd and a little less thc and terpene.
THERMAL DECARBOXYLATION OF URONIC ACIDS