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Bis(chloromethyl)ether (BCME) - US EPA
exposure to chloromethyl methyl ether, which itself is a lung irritant (1,2) Chronic inhalation exposure of mice to BCME has been reported to cause respiratory distress (1) EPA has not established a Reference Concentration (RfC) or a Reference Dose (RfD) for BCME (4) ATSDR has established an intermediate inhalation minimal risk level (MRL) of 0 0014 milligrams per cubic 3meter (mg/m) (0
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BIS-CHLOROMETHYL ETHER (BCME) Matrix: Air gas
CHLOROMETHYL METHYL ETHER (CMME) BIS-CHLOROMETHYL ETHER (BCME) Method no : 10 Matrix: Air Target concentration: 1 0 ppb (4 µg/m3 BCME, 3 2 µg/m3 CMME) Procedure: Collection in two "derivatizing reagent" bubblers connected in series The derivative is extracted with hexane and analyzed by gas chromatography using an electron capture detector Detection limit based on recommended air
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Perspectives Mortality Patterns Among Workers Exposed
Chloromethyl methyl ether (CMME)has been used extensively as a crosslinking agent for ion-exchange resins Commercial grades of CMMEare contaminated to the extent of 2-8 with bischloromethyl ether, an alkylating agent which has been shown to be a very potent lung carcinogen in animals Reports by other investigators in this and other countries have implicated CMMEas a lung carcinogen in
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Lung with chloromethyl manufacture: attwo factories
Chloromethyl methyl ether (CMME; C1CH2OCH3) is avolatile andhighly irritantliquid' thathasbeenused as amethylating agentin organicchemicalsynthesis in several countries since about 1948 Amajoruse of CMME has been the preparation of ion exchange resins in which a modified polystyrene resin is chloromethylated and then treated with a tertiary amine orpolyamine CMMEis synthesised byreacting Cited by : 16
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OverviewofPreventable Industrial Causes Occupational Cancer
and bischloromethyl ether are examples of associations between single agents and rare histologic types of cancer It is moredifficult to conduct epidemiologic studiesto identify cancer risks associated with complexmixtures Studiesof diesel exhaustand lung cancerandmetal machiningoils are cited as having employed advanced industrial hygiene and epidemiologic methodsfor studies of complex
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UICC Chapter VII
bischloromethyl ether (BCME) strongly suggests that exposure to this compound constitutes a serious human lung cancer hazard Epidemiological evidence also suggest that exposure to BCME may constitute a lung cancer risk amongst workers exposed to it as a contaminant in the manufacture of the related chloromethyl methyl ether (CMME) 17 A very large workforce is employed in the construction
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The Uncertain Consequences of Formaldehyde Toxicity
hydrogen chloride to form bischloromethyl ether (BCME), a known carcinogen that produces undifferentiated small cell carcinoma of the lung among exposed workers 8 Experimentally, it is known to produce carcinomas at other sites, including the nasal cavity 9 Any acid solution containing the chloride ion should be considered a source of BCME in the presence of formaldehyde,'0 so that apart from
Bis(chloromethyl) ether (BCME) and chloromethyl methyl ether (CMME) were considered by previous IARC Working Groups in 1973 and 1987 (IARC, 1974, 1987a)
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Data gathered under the authority of Section 16 of CEPA indicate that bis( chloromethyl) ether (BCME) and chloromethyl methyl ether (CMME) are not currently
bis chloromethyl eng
1 juil 1990 · Bis(chloromethyl) ether (BCME) and technical-grade chloromethyl methyl ether ( CMME) are known to be human carcinogens based on sufficient
bis chloromethyl ether
14 nov 2017 · In humans, exposure to vapors of chloromethyl methyl ether (CME) containing BCME as a contaminant led to increased incidence of chronic
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Bis(chloromethyl)ether (BCME) is no longer used commercially in the United States exposure to chloromethyl methyl ether, which itself is a lung irritant (1,2 )
bis chloromethyl ether
Technical-grade CMME contains 1-10 bis- chloromethyl ether (BCME) as a contaminant Because humans are exposed only to technical-grade CMME (a great
chloromethyl methyl ether volume
Bis(chloromethyl)ether and chloromethyl methyl eter References to Supplementary Web Tables, Section 2 Collingwood KW, Pasternack BS, Shore RE (1987)
F TableRefs
halo ethers, chloromethyl methyl ether (CMME) and bis(chloromethyl)ether ( BCME) The latter compound can be determined with a detection limit of l Ong
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28 juil. 1987 Cancer bronchique primitif. 40 ans. Travaux de fabrication du chlorométhyl-méthyl-éther. Page 3. Tableau ...
1 juil. 1990 Bis(chloromethyl) Ether and Technical-. Grade Chloromethyl Methyl Ether. CAS Nos. 542-88-1 and 107-30-2. Known to be human carcinogens.
1 juil. 1990 Bis(chloromethyl) Ether and Technical-. Grade Chloromethyl Methyl Ether. CAS Nos. 542-88-1 and 107-30-2. Known to be human carcinogens.
The carcinogenicity of bis-chloromethyl ether (BCME) and chloromethyl methyl ether. (CMME) (Section 1.1.2.) and the potential presence in the workplace of
Synonyms: BCME; Bis(chloromethyl) ether; chloromethyl ether (note: this name is sometimes used incorrectly for chlorome thyl methyl ether).
14 nov. 2017 Lung Cancer Mortality in Workers Exposed to Bis(Chloromethyl)Ether or Technical-Grade. Chloromethyl Methyl Ether .
Data gathered under the authority of Section 16 of CEPA indicate that bis(chloromethyl) ether (BCME) and chloromethyl methyl ether (CMME) are not currently
BIS(CHLOROMETHYL)ETHER AND CHLOROMETHYL METHYL ETHER 131 c. Other relevant data. No data were available on the genetic and related effects of chlornaphazine
bis(chloromethyl)ether vapors during the production and use of chemicals such as chloromethyl methyl ether in which bis(chloromethyl)ether may occur as a.
Bis(chloromethyl)ether (BCME) is no longer used commercially in the United exposure to chloromethyl methyl ether which itself is a lung irritant. (1
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