Is vitamin B12 a cofactor?
DOI: 10.1002/jimd.12009 Abstract Vitamin B12(cobalamin, Cbl) is a nutrient essential to human health. Due to its complex structure and dual cofactor forms, Cbl undergoes a complicated series of absorptive and processing steps before serving as cofactor for the enzymes methylmalonyl-CoA mutase and methionine synthase.
What is methionine synthase?
Methionine synthase catalyzes the methyl-Cbl dependent (re)methylation of homocysteine to methionine within the methionine cycle; a reaction required to produce this essential amino acid and generate S-adenosylmethionine, the most important cellular methyl-donor.
How are CBL and methionine biochemical pathways interlinked?
In sum, the Cbl, methionine, and folate biochemical pathways are interlinked with other crucial pathways in the cell, with each exerting regulatory influence on the other. Within the cell, metabolism of Cbl and folate is interrelated.
What is the relationship between CBL and folate?
Within the cell, metabolism of Cbl and folate is interrelated. These pathways are joined metabolically at the methionine cycle, but are connected by regulation through other cellular metabolic and regulatory pathways at many points.
Limportance de certaines vitamines du complexe B chez le porc