Objective To describe auxologic, physical, and behavioral features in a large cohort of males with 47,XYY (XYY), ages newborn to young adult Study design This is a cross-sectional descriptive study of male subjects with XYY who were evaluated at 1 of 2 specialized academic sites
47,XYY syndrome Other names: • Jacob’s syndrome • XYY karyotype Causes & risk factors 47,XYY syndrome is caused by • An extra copy of the Y • Each cell has a total of 47 chromosomes instead of the usual 46 Most cases of 47,XYY syndrome are not inherited The disorder usually occurs as a random event during
47,XYY syndrome is associated to higher risk for seizures, focal epilepsy, and an electroclinical pattern characterized by focal spike and waves (similar to benign focal epilepsy) has been described in 47,XYY boys (Torniero, 2010) Neuroimaging Males with 47,XYY show increased total gray matter (GM) and white matter (WM) volume
47,XYY Syndrome You have recently learned that your fetus has 47,XYY syndrome You had probably never heard of this condition before you had prenatal diagnosis This booklet was created to answer some of the many questions you may have What is 47,XYY syndrome? eother sex chromosom imbalances, 47,XYY
XYY syndrome (47,XYY) is a relatively common sex aneuploidy, occurring in approximately 1 of 1000 live male births (Morris et al , 2008), but remains largely underdiagnosed (Stochholm et al , 2010) Indeed, the condition is not associated with a clearly discernible physical phenotype, although individuals with 47,XYY present with
XYY syndrome XYY syndrome Approximately one boy in 1000 has XYY chromosomes In the cells of their body, instead of 46 chromosomes including one X and one Y chromosome, they have one X and two Y chromosomes, making 47 in all The impact of the extra Y chromosome is extremely variable The great majority of boys and men with an extra Y
A patient with 46,XY/47,XYY karyotype and female phenotype: a case report Zhi-Hui Liu†, Shi-Chao Zhou, Jun-Wen Du, Kun Zhang and Tao Wu*† Abstract Background: 47,XYY is a chromosomal abnormality syndrome that is typically observed in patients with a male phenotype Few patients with XYY syndrome will have infertility
47,XYY in Denmark, referred to here as index-persons As an index-person we accepted variants of 47,XYY including mosaics (46,XY/47,XYY) Due to their more severe phenotype 48,XXYY males (n = 23) and 48,XYYY males (n = 1) were not included as well as 47,XYY males with an autosomal aneuploidy (n = 1), as their sex chro-
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XYY - Unique
XYY syndrome XYY syndrome Approximately one boy in 1000 has XYY chromosomes In the cells of their body, instead of 46 chromosomes including one X and one Y chromosome, they have one X and two Y chromosomes, making 47 in all The impact of the extra Y chromosome is extremely variable The great majority of boys and men with an extra YTaille du fichier : 952KB
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XYY Syndrome - SSBP
47,XYY syndrome is associated to higher risk for seizures, focal epilepsy, and an electroclinical pattern characterized by focal spike and waves (similar to benign focal epilepsy) has been described in 47,XYY boys (Torniero, 2010) Neuroimaging Males with 47,XYY show increased total gray matter (GM) and white matter (WM) volume
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Issues and Challenges in XYY Syndrome
The 47,XYY syndrome, 50 years of certainties and doubts: A systematic review Aggression and Violent Behavior, 22, 9-17 doi:10 1016/j avb 2015 02 003 Ross, J L , N Tartaglia, D E Merry, M Dalva, and A R Zinn "Behavioral Phenotypes in Males with XYY and Possible Role of Increased NLGN4Y Expression in Autism Features " Genes, Brain and Behavior 14 2 (2015): 137-44
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Dysgonosomies X, XXY, XXX, XYY
IV 47,XYY Il s’agit de garçons plutôt grands présentant un phénotype normal La prévalence est de l’ordre de 1 p 1000 naissance garçon Cette prévalence est certainement sous diagnostiquée étant donné le phénotype normal associé à cette formule chromosomique Il n’existe pas de dysgénésie gonadique ou d’infertilité, ni de criminalitéTaille du fichier : 99KB
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Les Hommes XYY - Springer
Les Hommes XYY Andrologie (1994), 2, 197-204 Florence AMBLARD, Pierre JALBERT Laboratoire de Cytogdndtique, CHU de Grenoble - PB 317 X, 38043 Grenoble Cedex RESUME La constitution 47~YY est par ordre de fr~quence la 2bme dysgonosomie, elle repr~sente 1/851 /l Cited by : 1
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Caryotype47,XYY - :: eACLF
47,XYY:conclusions:) •)Lesindividusporteursd’uncaryotype47,XYY(etautres) trisomiesaffectantleschromosomessexuels):risque accrudeprésenterdesdifficultéscogniveset comportementales; •Donnéesinsuffisantes;desétudescomplémentaires sontnécessairespourconfirmerlanatureetlasévérité desdifficultésrencontrées,etlesmécanismesimpliqués
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Das XYY- Syndrom - Unique
Ein Junge von 1000 hat einen XYY-Chromosomensatz In ihren Körperzellen sind statt der üblichen 46 Chromosomen mit jeweils einem X- und einem Y-Chromosom 47 Chromosomen vorhanden, wobei ein X- und zwei Y-Chromosomen vorliegen Forscher haben die Anzahl der Jungen, bei denen ein XYY-Chromosomensatz festgestellt wurde, weil
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MMBFJ113 - N-Channel Switch
XYY = 3−Digit Date Code M = Date Code SOT−23 CASE 318BM ZXYY XXXX G S D G S D G S D G S D
chromosome Y mettent en ~vidence deux spots dans 1 h 5 ~ des spermatozoides, ce qui est proche de la fr~quence des hommes XYY dans la population
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XYY Collège National des Enseignants et Praticiens de Génétique Médicale Date de création du document 2010-2011 - © Université Médicale Virtuelle
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Le syndrome 47,XYY : retrouvé dans 0 1 de la populaoon masculine générale ( Jacobs et al , 1974), •le chr Y chromosome résulte de la non-‐disjoncoon
Blondeel XYY
Le caryotype démontre que le patient est por- teur d'une constitution chromosomique 47, XYY, ainsi que d'une inversion péricentrique d'un des deux
revM C A dLi C A ge Gusbin
Le caryotype démontre que le patient est por- teur d'une constitution chromosomique 47, XYY, ainsi que d'une inversion péricentrique d'un des deux
revM C A dLi C A ge Gusbin
One such sex chromosome aneuploidy, 47XYY, is a clear example of this problem When the XYY genotype was first recognised1 it was thought to be oflittle
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