PRODUCT MONOGRAPH PrCLAFORAN® Cefotaxime for injection, M Std 1g and 2g cefotaxime (as cefotaxime sodium) per vial β-lactam Antibiotic sanofi-aventis Canada Inc
Claforan ™ (cefotaxime 1g single dose ADD-Vantage™ glass vial 0039-0023-25 1 g/ 10 mL vial 0143-9931-25 2 g single-dose glass fliptop vial 0039-0019-10
1g vial (IM) 3 3 4 300 2g vial (IM) 5 6 0 330 1g vial (IV) 10 10 4 95 2g vial (IV) 10 11 0 180 Shake to dissolve; inspect for particulate matter and discoloration prior to use Solutions of CLAFORAN range from very pale yellow to light amber, depending on concentration, diluent used, and length and condition of storage
2 Before you have Claforan 3 How to have Claforan 4 Possible side effects 5 How to store Claforan 6 Further information 1 What Claforan is and what it is used for The name of your medicine is Claforan Powder for Solution for Injection 500mg or Claforan Powder for Solution for Injection 1g (called Claforan throughout this leaflet)
CEFOTAXIME CEFOTAXIME® CLAFORAN® Flacon 500mg, 1g, 2g Voie intraveineuse Ce médicament est un antibiotique Il ne doit pas être interrompu sans avis médical
IV: Powder for reconstitution: 500mg, 1g, 2g, 10g, 20g Intravenous Solution: 1g/50mL, 2 g/50mL Dosing in adults: Meningitis: 1-2 g IV/IM q8h Bone and/or joint infection: 1-2g IV/IM q8h Gonococcal urethritis: 0 5g IM x 1 dose Lower respiratory tract infection: 1-2 g IV/IM q8h Bacterial peritonitis: 1-2g q8-12h Dosing in pediatrics:
Claforan Powder for Solution for Injection 1g not available PA 540/37/3 SANOFI-AVENTIS IRELAND LTD IE Claforan Powder for Solution for Injection 500mg not available PA 540/37/2 SANOFI-AVENTIS IRELAND LTD IE Claforan pulver till injektions -/infusionsvätska, lösning not available 20547 SANOFI AB SE
Add 9 6mL of water for injections to a 1g vial Concentration is 1000mg/10mL = 100mg/mL IV Infusion: Step 1: Reconstitution Add 9 6mL of water for injections to a 1g vial Concentration is 1000mg/10mL = 100mg/mL Step 2: Dilution Take 2mL (200mg) of the above solution and make to a final volume of 5mL with a compatible diluent
The name of your medicine is cefotaxime 500mg, 1g or 2g powder for solution for injection or infusion In the rest of this leaflet it is called cefotaxime for injection In this leaflet: 1 t cefotaxime for injection is and what it is used for Wha 2 Before you are given cefotaxime for injection 3 How cefotaxime for injection should be given 4
, comparing intramuscular ceftriaxone (1g daily) with oral moxafloxacin over a 5 day treatment course Both agents showed equal efficacy in the per protocol population Ceftriaxone has utility in cases of AECB, although the supporting stud y was small Nevertheless, ceftriaxone has a place where intravenous treatment is needed
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MONOGRAPHIE DE PRODUIT
CLAFORAN (céfotaxime pour injection-synthétique du groupe des ) est un antibiotique semi céphalosporines 2aminothiazolyl pour administration parentérale Les résultats des études - in vitro démontrent que son activité antibactérienne découle de l’altération de la synthèse de la paroi cellulaire CLAFORAN fait montre de stabilité contre l’action de la plupart des
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GUIDE D’ANTIBIOTHÉRAPIE PROBABILISTE / ADULTE
POURQUOI CEFOTAXIME (CLAFORAN®) PLUTÔT QUE CEFTRIAXONE (ROCEPHINE®) ? On sait que la prise antérieure de C3G est un facteur de risque majeur de la résistance des entérobactéries aux C3G Ce risque varie selon la C3G utilisée et est plus
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UTILISATION PRATIQUE DES ANTI-INFECTIEUX Date : 10/2017
CLAFORAN • Eau PPI • IM : 4mL (250mg/mL) • IV : 4-10mL (100-250mg/mL) • NaCl0,9 ou G5 • 50-100mL • Conc Max : 20mg/ml • IV perfusion (20-60min) : préférentiel chez l'enfant • IV perfusion continue sur 12h toutes les 12h • 24H à T°amb • 24h à T°amb • IVD Céfoxitine MEFOXIN • Eau PPI • IV : 10mL (conc : 100mg/ml)
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Adaptation posologique des principaux Antibiotiques à la
CLAFORAN (NSFP) Céfotaxime 1-2g/8h MEFOXIN (NSFP) Céfoxitine 1-2g/8h (3-6g par jour) ORELOX Cefpodoxime 100-200mg/12h ZINFORO Ceftaroline 600mg/12h Ceftazidime /Discontinu 2g/8h Ceftazidime /Continu 2g puis 6g/24h MABELIO Ceftobiprole 500mg/8h ZERBAXA Ceftolozane + Tazobactam 1g/0,5g/8h ROCEPHINE Céftriaxone 1-2g/24h ZINNAT PO Céfuroxime 250-500 mg/12h
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GUIDE DU BON USAGE DES ANTIBIOTIQUES
° associé à CEFOTAXIME (claforan) : 200mg / kg/ jour en 4 perfusions méningocoque suspecté : ° CEFTRIAXONE (rocéphine) : 2g / jour listéria suspectée : ° AMOXICILLINE (clamoxyl) : 200mg / kg / jour en 4 perfusions ° associé à GENTAMICINE (gentalline) : 3mg / kg/ jour en 1 perfusion
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Les infections néonatales Les infections néonatales
Claforan : 100-200mg /kg /j/IV en 2fois Amikacine 15mg /kg /ivl 1seule fois Si orientation bactério/LG bithérapie : Si SB :coccigram+ péni G+Amikacine Si BGN BGN claforan+Amikacine Si bacilleG+ amoxicilline +Amikacine
sodium à raison de 2 g pour 1 litre de glucosé à 5 Tous ces malades ont été hospitalisés et ayant l'administration de la 1ère dose de Claforan, des
CLAFORAN ® (céfotaxime)/ ROCEPHINE ® (ceftriaxone) résistantes ou intermédiaires au Claforan ®, 43 pour Enterobacter cloacae, 10 pour
claforan
EXPERTS Benoît Veber (Rouen), Claude Martin (Marseille), Philippe Montravers (Amiens), Alain Lepape (Lyon), Rémy Gauzit (Bondy), Jean-Claude Granry
ATBprop sepsisgrave
12/03/2014 07:34 - VISTAlink folder 1128235 - Page 1/3 CLAFORAN® 1,0 g poudre et solvant pour solution injectable IM/IV en flacon céfotaxime sodique
Le relais per os précoce d'une antibiothérapie initiée par voie intraveineuse avec les même molécules ou avec des molécules différentes actives sur les germes
Reanimation Vol N p
Cefotaxime for injection Mfr. Std. 1g and 2g cefotaxime (as cefotaxime sodium) per vial ?-lactam Antibiotic. ACTION AND CLINICAL PHARMACOLOGY. CLAFORAN
Injection 500mg or Claforan Powder for Solution for Injection. 1g (called Claforan throughout this leaflet). Claforan contains a medicine called Cefotaxime.
Claforan Powder for Solution for Injection 1g. 2. QUALITATIVE AND QUANTITATIVE COMPOSITION. Each vial contains cefotaxime sodium equivalent to.
Each vial of Claforan 0.25g contains 262mg cefotaxime sodium as dry Dosage in Gonorrhoea: A single injection of 1g may be administered.
03-Sept-2019 Claforan Powder for Solution for Injection 1g. 2 QUALITATIVE AND QUANTITATIVE COMPOSITION. Each vial contains cefotaxime sodium equivalent ...
Claforan (an antibiotic from the group called cephalosporins) is a Claforan mixed with lidocaine for intramuscular injection must not be used in.
CLAFORAN (cefotaxime for injection) is a semi-synthetic 2-aminothiazolyl cephalosporin antibiotic for parenteral use In vitro studies indicate that the antibacterial action of CLAFORAN results from inhibition of cell wall synthesis It is stable against the action of most ?-lactamases
What Is Claforan?
Claforan is a cephalosporin (SEF a low spor in) antibiotic. Claforan is used to treat many kinds of bacterial infections, including severe or life-threatening forms. This medicine is also used to prevent infection in people having certain types of surgery. Claforan may also be used for purposes not listed in this medication guide.
Warnings
You should not use Claforan if you are allergic to Claforan or another cephalosporin antibiotic (cefdinir, cefalexin, Keflex, Omnicef, and others).
Before Taking This Medicine
You should not use Claforan if you have ever had a severe allergic reaction to any type of cephalosporin antibiotic (cefdinir, cefalexin, Keflex, Omnicef, and others). Tell your doctor if you have ever had: 1. an allergy to penicillin; 2. kidney disease; 3. liver disease; 4. a stomach or intestinal disorder such as colitis; 5. diabetes; or 6. heart...
How Should I Use Claforan?
Claforan is injected into a muscle, or given as an infusion into a vein. A healthcare provider will give you this injection when Claforan is used to prevent infection from surgery. A healthcare provider may teach you how to properly use the medication by yourself to treat an infection. Read and carefully follow any Instructions for Use provided wit...
What Happens If I Miss A dose?
Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time. If you are receiving this medicine at a clinic, call your doctor if you miss an appointment for your injection.
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include weakness, cold feeling, pale skin, blue lips, or seizure (convulsions).
What Should I Avoid While Using Claforan?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Claforan Side Effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rashthat spreads and causes blistering and peeling). Claforan may cause serious side effects. Call your doctor at once i...
What Other Drugs Will Affect Claforan?
Tell your doctor about all your other medicines, especially: 1. another injected antibiotic; or 2. a diuretic or "water pill." This list is not complete. Other drugs may affect Claforan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
What is the dosage of Claforan?
CLAFORAN may be administered IM or IV after reconstitution. Premixed CLAFORAN Injection is intended for IV administration after thawing. The maximum daily dosage should not exceed 12 grams. GUIDELINES FOR DOSAGE OF CLAFORAN
What is the difference between cefotaxime and Claforan?
CLAFORAN, equivalent to 1 gram and 2 grams cefotaxime, is supplied as frozen, premixed, iso-osmotic injections in plastic containers. Solutions range from very pale yellow to light amber. Dextrose Hydrous, USP has been added to adjust osmolality (approximately 1.7 g and 700 mg to the 1 g and 2 g cefotaxime dosages, respectively).
How does Claforan work?
Claforan is injected into a muscle, or given as an infusion into a vein. A healthcare provider will give you this injection when Claforan is used to prevent infection from surgery. A healthcare provider may teach you how to properly use the medication by yourself to treat an infection.
What are the side effects of Claforan?
Liver - Transient elevations in SGOT, SGPT, serum LDH, and serum alkaline phosphatase levels have been reported. Kidney - As with some other cephalosporins, interstitial nephritis and transient elevations of BUN and creatinine have been occasionally observed with CLAFORAN.
CLAFORAN®