Aspirin can be made by reacting salicylic acid with acetic acid in the presence of an acid catalyst The phenol group on the salicylic acid forms an ester with the carboxyl group on the acetic acid However, this reaction is slow and has a relatively low yield
Synthesis of Aspirin
To prepare aspirin, salicylic acid is reacted with an excess of acetic anhydride A small amount of a strong acid is used as a catalyst which speeds up the reaction
exp aspirinf
Thus, salicylic acid can react with nucleophilic molecules like methanol in addition to reacting with electrophilic molecules like acetic anhydride The reaction of
esterification salicylic acid
Reaction OH OH O salicylic acid O O O acetic anhydride O OH HO O O acetyl salicylic acid (aspirin) OH O acetic acid H2SO4 heat + +
aspirin
acetic anhydride OH O OH salicylic acid OH O C H Using familiar A' level chemistry, you will produce aspirin using an esterification reaction with ethanoic
Aspirin
Figure 5: Acetylation of salicylic acid Risk Assessment Acetylsalicylate and salicylic acid are combustible and harmful if swallowed Acetic anhydride is corrosive,
Lab Manual Synthesis of Aspirin web
In this experiment, you will use salicylic acid, acetic anhydride water Un- reacted acetic anhydride will be hydrolyzed to vinegar and 85 phosphoric acid will
Experiment
In this experiment you will synthesize aspirin from acetic anhydride and salicylic acid using phosphoric acid as a catalyst to speed up the reaction (it is not a
Lab AspirinSynthesisupdatedPSGF
salicylic acid reacts with acetic acid to produce the ester and water. This reaction like most esterification reactions
(acetylsalicylic acid also known as aspirin) was shown to be much less Aspirin can be made by reacting salicylic acid with acetic acid in the presence ...
In the presence of moisture aspirin may decompose (hydrolysis) into salicylic acid and acetic acid. This reaction is the reverse of the synthesis reaction. The
Learn the major chemical reaction of carboxylic acids and esters and learn how to Produced by reacting salicylic acid with acetic.
It was eventually discovered that salicylic acid is the portion of these complete reaction in the preparation of an acetate ester is to use acetic.
Esters are produced by the reaction between alcohols and carboxylic acids. For example reacting ethanol with acetic acid to give ethyl acetate is shown
the effects of diverse ions. THE reaction between salicylic acid and ferric ion in acetic acid solution to give an amethyst coloration has.
Salicylic acid reacts with acetic anhydride to form aspirin acetylsalicylic acid. If the percent yield in this reaction is 78.5%
Salicylic Acid by Nitration Reaction . Insoluble in water and soluble in 85 % acetic acid and ethanol. 3. Boiling point is about 117 oC.
acetic acid change the selectivity of the separation of sal- It is acidified to give the desired salicylic acid. The main reaction is shown in Figure 1; ...
1 University of Wisconsin Chemistry 116 Preparation and