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•Long, costly, and inherently risky: only 1 of 10-15,000 reach FDA approval • Toxicology testing is required to demonstrate that drugs are safe before they can be given to humans Why do Toxicology Testing?
Exposure Effect Efficacy Toxicity Desired Efficacy (eg ED 90) Acceptable Toxicity (Normally the ‘ No observed adverse effect level ’ or NOAEL)
Chemistry and Toxicology Guide for Specimen Acceptability and Add-on Requests Test Name Acceptable Tube Types Specimen Received UNSEPARATED (UNSPUN) Specimen ADD-ON Received (Aliquoted SEPARATED plasma/serum or (Aliquoted spun SST/PST) plasma/serum or Specimen uncapped Spun SST/PST) at RT for up to 8hr Kept cool during then stored
WHY DOES IT TAKE SO LONG? By Jeff Eitner, Springfield Lab In this Issue: • Toxicology Results Timelines Explained • Collection of Blood and Urine Samples for Tox Testing • New Opioid Drugs Implicated in Oregon Deaths • A New Tox Instrument Promises Improved Analysis • Tox Top 24: 2016 vs 2011 OREGON STATE POLICE
If there is any question of a toxicological involvement in the death the case must be to provide long-term information on drug compliance or abstinence
are no specific up-to-date guidelines on forensic toxicology investigations for ' multi-target' screening can be applied to a huge list of substances, as long as
An autopsy is a medical examination of a body after death contributed to death , the death certificate may not be finalized until the toxicology results are
How Long Does Testing Take? The window for receiving toxicology results back from the laboratory varied from office to office due to multiple factors, including