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Antibiotics are produced through complex, multi-step pathways, the genes for which are encoded in large biosynthetic gene clusters which may include the
Genetic Engineering of Antibiotic-Producing Microorganisms Haruo Ikeda 17 1 Introduction Many antibiotics are produced by strains of the genus
With the demonstration of the production of novel metabolites by synthase engineering, the stage is excitingly set for rationally manipulating synthase '
that manipulation of antibiotic biosynthesis genes would result in the overproduction of antibiotics and lead to the synthesis of novel products
The application of directed selection techniques and genetic engineering are used to alter the genetics of antibiotic producers in a semirandom fashion